Prostate Cancer P D:美国退伍军人前列腺癌患者中的抽烟与死亡率关系研究

2019-10-27 Alex Yang MedSci原创

抽烟是一些泌尿生殖系统癌症死亡的一个风险因子,很可能是致癌物质在尿液中的积累导致。然而,在前列腺癌中抽烟与死亡率的关系还很少研究。最近,有研究人员评估了诊断为PC的抽烟者、有抽烟历史者和从不抽烟者中前列腺癌特异性死亡率(PCSM)的差异。研究是一个回顾性的群体研究,包括了73668名男性(抽烟者:22608名(30.7%)、有抽烟历史者:23695(32.1%)和从不抽烟者:27365(37.1%

抽烟是一些泌尿生殖系统癌症死亡的一个风险因子,很可能是致癌物质在尿液中的积累导致。然而,在前列腺癌中抽烟与死亡率的关系还很少研究。最近,有研究人员评估了诊断为PC的抽烟者、有抽烟历史者和从不抽烟者中前列腺癌特异性死亡率(PCSM)的差异。

研究是一个回顾性的群体研究,包括了73668名男性(抽烟者:22608名(30.7%)、有抽烟历史者:23695(32.1%)和从不抽烟者:27365(37.1%))。平均的跟踪调查时间为5.9年。研究发现,抽烟者患PC的时间更早(平均63岁,从不抽烟为66岁;p<0.001),并且具有更加晚期的疾病阶段(抽烟者中阶段IV占比5.3%,从不抽烟者中占比4.3%;p<0.04)。PCSM的10年发生率在抽烟者、有抽烟历史者和从不抽烟者中的比例分别为5.2%、4.8%和4.5%。在竞争性风险回归中,抽烟者与PCSM风险的增加相关(子分布风险比:1.14,95%CI:(1.05-1.24),p=0.002),而具有抽烟历史者不存在上述关系。分层回归分析表明了该风险的增加能够部分的归因于肿瘤特征。

最后,研究人员指出,诊断时抽烟与与PC和其他原因更高风险的死亡相关。相反,过去抽烟与PCSM不相关,表明了抽烟可能是一个可以修正的风险因子。PC诊断也许是讨论戒烟的重要机会。

原始出处:

Paul Riviere, Abhishek Kumar, Elaine Luterstein et al. Tobacco smoking and death from prostate cancer in US veterans. Prostate Cancer P D. 17 Oct 2019

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    2019-10-29 lsndxfj
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    2019-10-29 gujh
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    2019-10-29 sunylz
  6. [GetPortalCommentsPageByObjectIdResponse(id=1648684, encodeId=30f916486843f, content=<a href='/topic/show?id=718f9464852' target=_blank style='color:#2F92EE;'>#退伍军人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94648, encryptionId=718f9464852, topicName=退伍军人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9d23641338, createdName=smlt2016, createdTime=Thu Nov 14 20:11:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791591, encodeId=78f81e9159151, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sat Nov 16 15:11:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364538, encodeId=7fe4136453807, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue Oct 29 11:11:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385580, encodeId=3d0113855803d, content=<a href='/topic/show?id=83865610462' target=_blank style='color:#2F92EE;'>#抽烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56104, encryptionId=83865610462, topicName=抽烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Tue Oct 29 11:11:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602206, encodeId=bfad16022065b, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Oct 29 11:11:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374554, encodeId=d7dc3e4554a6, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Tue Oct 29 07:40:15 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040577, encodeId=1a7d10405e746, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Oct 27 23:11:00 CST 2019, time=2019-10-27, status=1, ipAttribution=)]
    2019-10-29 txqjm

    谢谢了,学习

    0

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    2019-10-27 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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