ASCO2017:维生素D也是宝!高剂量维生素D或延缓转移性结直肠癌进展

2017-05-24 鱼会飞 艾兰博曼医学网

一项由Dana-Farber癌症研究所研究人员开展的一项多机构的维生素D随机、单盲治疗癌症患者临床试验发现,高剂量微生物或可减缓转移性结直肠癌患者的疾病进展,相关研究结果发表在6月2-6日在美国芝加哥举行的第53届美国临床肿瘤学会年会(ASCO)上。

一项由Dana-Farber癌症研究所研究人员开展的一项多机构的维生素D随机、单盲治疗癌症患者临床试验发现,高剂量微生物或可减缓转移性结直肠癌患者的疾病进展,相关研究结果发表在6月2-6日在美国芝加哥举行的第53届美国临床肿瘤学会年会(ASCO)上。

Dana-Farber胃肠道肿瘤学研究中心的主任Kimme Ng博士表示:“直至开展了这一研究才发现维生素D与转移性结直肠癌之间的关系”。 Ng博士将在ASCO会议上介绍SUNSHINE研究的早期成果。与此同时,患者可以与医生沟通检测其血液中维生素D的含量,并考虑服用补充剂维持血液中的剂量。

Ng博士表示这些研究数据需要在较大的研究中得到确认,但是对于转移性结直肠癌患者,采用高剂量维生素D与标准治疗方式相结合的方式似乎是有益的。

研究人员对139例接受化疗和贝伐珠单抗联合治疗的患者进行了临床试验。然后将患者随机分配到高剂量维生素D(8000单位/天,持续2周,每天三次,后续进行8000单位/天的治疗),或者每天服用400单位(通常由多种维生素丸提供的水平)作为对照组。

服用高剂量的结直肠癌患者疾病发生进展前中位数为13.1个月,对照组为11.2个月。在转移性癌症患者的世界里,2个月的差距是非常大的。建立补偿模型以消除年龄及先前存在的疾病情况等影响因素,在大约17个的中位随访期间,高剂量组的患者无进展生存期提高了33%。

其他试验结果表明,接受高剂量维生素D的患者比接受低剂量维生素D的患者更易经常发生腹泻。这种差别还没有达到统计学意义,可能与SUNSHINE试验中患者数量相对较少,高剂量组的患者更多的进行了手术驱除转移性肿瘤,也可能会有助于患者疾病的治愈。但是临床试验观察分析表明,血液中维生素D水平的较高的患者其无进展生存期和总生存期明显更好。

这项研究成果还需要更大型的研究来验证。基于以上研究结果,研究人员认为III期临床研究是必要的。


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    2018-03-31 quxin068
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    2017-12-18 amy0550
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    2017-05-30 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-05-24 flysky120

    维生素D还有这个作用

    0

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    2017-05-24 执着追梦

    耳目一新,值得思考

    0

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    2017-05-24 明月清辉

    谢谢分享,学习了

    0

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