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Macromol Biosci：BCPx/PMMA骨水泥可有效恢复骨缺损

2019-10-03 不详 网络

关注

聚甲基丙烯酸甲酯（PMMA）骨水泥由于其良好的生物力学性能和快速固化而被广泛用于椎体骨折的修复。但是，PMMA水泥的生物惰性可能会导致界面松弛，疲劳，断裂和最终破坏。在这项研究中，将双相磷酸钙（BCP）引入PMMA水泥中以制备可注射的复合骨水泥（BCPx / PMMA），并优化BCP的含量以达到与骨骼再生相匹配的适当吸收率。结果显示，BCPx / PMMA骨水泥的抗压强度符合国际标准化组织标准58

聚甲基丙烯酸甲酯（PMMA）骨水泥由于其良好的生物力学性能和快速固化而被广泛用于椎体骨折的修复。但是，PMMA水泥的生物惰性可能会导致界面松弛，疲劳，断裂和最终破坏。在这项研究中，将双相磷酸钙（BCP）引入PMMA水泥中以制备可注射的复合骨水泥（BCPx / PMMA），并优化BCP的含量以达到与骨骼再生相匹配的适当吸收率。

结果显示，BCPx / PMMA骨水泥的抗压强度符合国际标准化组织标准5833，并且可以促进Sprague-Dawley大鼠骨髓间充质干细胞的生物矿化以及粘附，增殖和成骨分化。此外，在兔radius骨缺损模型上进行的体内测试表明，BCP的存在可以显著改善PMMA水泥的成骨功效。

综上所述，作为有前途的可注射生物材料，BCPx/PMMA骨水泥在骨组织再生中具有巨大的潜力。

原始出处：

Zhang X, Kang T, et al., Biological Activity of an Injectable Biphasic Calcium Phosphate/PMMA Bone Cement for Induced Osteogensis in Rabbit Model. Macromol Biosci. 2018 Mar;18(3). doi: 10.1002/mabi.201700331. Epub 2018 Jan 25.

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    2020-07-30 yb6560

    #MAC#

    0

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    2020-05-13 jiafufeng@yaho

    #CRO#

    0

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    2020-07-17 sunylz

    #Bio#

    0

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    2019-10-05 zhs3882

    #骨水泥#

    0

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    2019-10-05 10518094zz

    #ACR#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1996316, encodeId=08f01996316b7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Jul 30 23:26:00 CST 2020, time=2020-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857837, encodeId=ffdb185e8372d, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Wed May 13 18:26:00 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918872, encodeId=34e619188e27f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Jul 17 01:26:00 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370342, encodeId=d6c613e034228, content=<a href='/topic/show?id=b103101e18e7' target=_blank style='color:#2F92EE;'>#骨水泥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101718, encryptionId=b103101e18e7, topicName=骨水泥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sat Oct 05 13:26:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400444, encodeId=6221140044463, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Oct 05 13:26:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419332, encodeId=dd28141933231, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Oct 05 13:26:00 CST 2019, time=2019-10-05, status=1, ipAttribution=)]
    2019-10-05 lfcmxl

    #骨缺损#

    0