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Advaxis的axalimogene filolisbac与阿斯利康Imfinzi的联合研究取得进展

2018-07-16 MedSci MedSci原创

AdvaxisImfinzi宫颈癌
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Advaxis于2018年7月13日表示，FDA批准了一项I/II期临床研究，该研究联合了阿斯利康的Imfinzi（durvalumab）与Advaxis的axalimogene filolisbac治疗晚期、复发难治性人乳头瘤病毒（HPV）相关宫颈癌和HPV患者相关的头颈癌。Durvalumab是阿斯利康旗下的一款抗PD-L1单抗药物，用于膀胱癌、肺癌等多种癌症的治疗。

Advaxis于2018年7月13日表示，FDA批准了一项I/II期临床研究，该研究联合了阿斯利康的Imfinzi（durvalumab）与Advaxis的axalimogene filolisbac治疗晚期、复发难治性人乳头瘤病毒（HPV）相关宫颈癌和HPV患者相关的头颈癌。Durvalumab是阿斯利康旗下的一款抗PD-L1单抗药物，用于膀胱癌、肺癌等多种癌症的治疗。

Advaxis首席执行官Kenneth Berlin表示：“我们很高兴能够解决这个问题，并将根据需要在Advaxis的产品组合中实施这些指导方针”。Axalimogene filolisbac是一种基于单核细胞增生李斯特菌的靶向免疫疗法，旨在治疗HPV相关癌症。早在2015年，Axalimogene filolisbac就已经取得了中期积极的研究结果，被视作罗氏公司的重磅炸弹药物阿瓦斯汀的直接竞争对手。

宫颈癌是最常见的妇科恶性肿瘤。原位癌高发年龄为30～35岁，浸润癌为45～55岁，近年来其发病有年轻化的趋势。宫颈癌是全球女性癌症死亡的主要原因，美国每年宫颈癌新增病例约为12000例。


原始出处：

http://www.firstwordpharma.com/node/1578748#axzz5LPwlfcKL

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    2018-11-10 zhangfenasdf

    #Advaxis#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2048227, encodeId=aea1204822e7f, content=<a href='/topic/show?id=b9bd2033a0' target=_blank style='color:#2F92EE;'>#Advaxis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2033, encryptionId=b9bd2033a0, topicName=Advaxis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc9246, createdName=zhangfenasdf, createdTime=Sat Nov 10 15:16:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049058, encodeId=144920490589e, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Jul 23 22:16:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334413, encodeId=a2d5334413df, content=阿瓦斯汀岌岌可危，对于患者是福气, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibD3KHkWpogYEBFLLhK39cF0geS1c8Z7AcaU6HFrV3tTmVHO1gicfzJX0b9axNXIDufnATKNrja9A/132, createdBy=e9992409610, createdName=Qing～～, createdTime=Fri Jul 27 01:56:29 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416490, encodeId=2ec11416490cb, content=<a href='/topic/show?id=93ce9e60cc' target=_blank style='color:#2F92EE;'>#Imfinzi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9760, encryptionId=93ce9e60cc, topicName=Imfinzi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34be3191285, createdName=swallow, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585380, encodeId=78781585380ba, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332226, encodeId=d75933222678, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jul 17 10:56:46 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332209, encodeId=fc1933220969, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Tue Jul 17 09:42:05 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-23 cy0324

    #Gene#

    0

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    2018-07-27 Qing～～

    阿瓦斯汀岌岌可危，对于患者是福气

    0

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    2018-07-18 swallow

    #Imfinzi#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2048227, encodeId=aea1204822e7f, content=<a href='/topic/show?id=b9bd2033a0' target=_blank style='color:#2F92EE;'>#Advaxis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2033, encryptionId=b9bd2033a0, topicName=Advaxis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc9246, createdName=zhangfenasdf, createdTime=Sat Nov 10 15:16:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049058, encodeId=144920490589e, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Jul 23 22:16:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334413, encodeId=a2d5334413df, content=阿瓦斯汀岌岌可危，对于患者是福气, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibD3KHkWpogYEBFLLhK39cF0geS1c8Z7AcaU6HFrV3tTmVHO1gicfzJX0b9axNXIDufnATKNrja9A/132, createdBy=e9992409610, createdName=Qing～～, createdTime=Fri Jul 27 01:56:29 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416490, encodeId=2ec11416490cb, content=<a href='/topic/show?id=93ce9e60cc' target=_blank style='color:#2F92EE;'>#Imfinzi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9760, encryptionId=93ce9e60cc, topicName=Imfinzi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34be3191285, createdName=swallow, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585380, encodeId=78781585380ba, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332226, encodeId=d75933222678, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jul 17 10:56:46 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332209, encodeId=fc1933220969, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Tue Jul 17 09:42:05 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-18 Boyinsh

    #MOG#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2048227, encodeId=aea1204822e7f, content=<a href='/topic/show?id=b9bd2033a0' target=_blank style='color:#2F92EE;'>#Advaxis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2033, encryptionId=b9bd2033a0, topicName=Advaxis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc9246, createdName=zhangfenasdf, createdTime=Sat Nov 10 15:16:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049058, encodeId=144920490589e, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Jul 23 22:16:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334413, encodeId=a2d5334413df, content=阿瓦斯汀岌岌可危，对于患者是福气, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibD3KHkWpogYEBFLLhK39cF0geS1c8Z7AcaU6HFrV3tTmVHO1gicfzJX0b9axNXIDufnATKNrja9A/132, createdBy=e9992409610, createdName=Qing～～, createdTime=Fri Jul 27 01:56:29 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416490, encodeId=2ec11416490cb, content=<a href='/topic/show?id=93ce9e60cc' target=_blank style='color:#2F92EE;'>#Imfinzi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9760, encryptionId=93ce9e60cc, topicName=Imfinzi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34be3191285, createdName=swallow, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585380, encodeId=78781585380ba, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332226, encodeId=d75933222678, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jul 17 10:56:46 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332209, encodeId=fc1933220969, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Tue Jul 17 09:42:05 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 虈亣靌

    优质资源.共同学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2048227, encodeId=aea1204822e7f, content=<a href='/topic/show?id=b9bd2033a0' target=_blank style='color:#2F92EE;'>#Advaxis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2033, encryptionId=b9bd2033a0, topicName=Advaxis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fc9246, createdName=zhangfenasdf, createdTime=Sat Nov 10 15:16:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049058, encodeId=144920490589e, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Jul 23 22:16:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334413, encodeId=a2d5334413df, content=阿瓦斯汀岌岌可危，对于患者是福气, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJibD3KHkWpogYEBFLLhK39cF0geS1c8Z7AcaU6HFrV3tTmVHO1gicfzJX0b9axNXIDufnATKNrja9A/132, createdBy=e9992409610, createdName=Qing～～, createdTime=Fri Jul 27 01:56:29 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416490, encodeId=2ec11416490cb, content=<a href='/topic/show?id=93ce9e60cc' target=_blank style='color:#2F92EE;'>#Imfinzi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9760, encryptionId=93ce9e60cc, topicName=Imfinzi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34be3191285, createdName=swallow, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585380, encodeId=78781585380ba, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Wed Jul 18 13:16:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332226, encodeId=d75933222678, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jul 17 10:56:46 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332209, encodeId=fc1933220969, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Tue Jul 17 09:42:05 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 易水河

    学习学习很好

    0