NRR:长段周围神经损伤修复的生物材料

2013-09-05 伊文 EurekAlert中文版

  对于周围神经,现在应用比较普遍的是自体或同种异体神经移植,后者与异种异体移植一样存在免疫排斥的问题。应用神经导管修复周围神经缺损的研究主要集中在小于30mm缺损的修复。伊朗伊斯兰阿扎德大学的Esmaeil Biazar博士所在研究组研究了纳米纤维聚羟基丁酸戊酸共聚酯(PHBV)神经导管修复大于30mm长段坐骨神经的缺损。4个月后,大体观察和组织学评估发现纳米纤维导管内的坐骨神

对于周围神经,现在应用比较普遍的是自体或同种异体神经移植,后者与异种异体移植一样存在免疫排斥的问题。应用神经导管修复周围神经缺损的研究主要集中在小于30mm缺损的修复。伊朗伊斯兰阿扎德大学的Esmaeil Biazar博士所在研究组研究了纳米纤维聚羟基丁酸戊酸共聚酯(PHBV)神经导管修复大于30mm长段坐骨神经的缺损。4个月后,大体观察和组织学评估发现纳米纤维导管内的坐骨神经发生再生,且神经纤维连续,可见有髓鞘神经纤维的形成,再生的神经中出现许旺细胞和胶质细胞,Masson’s三色染色显示移植纳米纤维导管的腓肠肌肌细胞无病理改变。说明纳米纤维聚羟基丁酸戊酸共聚酯(PHBV)神经导管可用于修复长段坐骨神经缺损。实验的意义在于为临床长段周围神经缺损修复提供了新技术方向。相关研究成果发表于2013年8月第24期《中国神经再生研究(英文版)》杂志中。


                 

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