交大科研人员发现胃癌腹膜转移病变关键驱动基因

2015-10-29 佚名 中国新闻网

上海交通大学医学院附属瑞金医院针对胃癌发生腹膜转移不治之症开展的全基因组与全转录组研究成果,近日发表于《科学报告》。该研究由朱正纲、于颖彦共同领衔,为预测胃癌腹膜转移及该类病人的靶向治疗药物开发等提供了新依据。 胃癌是威胁生命的消化道恶性肿瘤,致死率极高。但长久以来受到病例样本来源、实验模型以及实验手段所限,胃癌腹膜转移的分子机制研究进展缓慢,针对胃癌腹膜转移这一世界性难题一直缺乏有效的治疗

上海交通大学医学院附属瑞金医院针对胃癌发生腹膜转移不治之症开展的全基因组与全转录组研究成果,近日发表于《科学报告》。该研究由朱正纲、于颖彦共同领衔,为预测胃癌腹膜转移及该类病人的靶向治疗药物开发等提供了新依据。

胃癌是威胁生命的消化道恶性肿瘤,致死率极高。但长久以来受到病例样本来源、实验模型以及实验手段所限,胃癌腹膜转移的分子机制研究进展缓慢,针对胃癌腹膜转移这一世界性难题一直缺乏有效的治疗对策。

瑞金医院消化外科研究所科研人员与胃癌临床团队合作,将全基因组测序与全转录组测序研究引入到胃癌腹膜转移机制探索当中,发现了第一批从慢性胃炎—胃癌—腹膜转移病变演进过程的关键驱动基因,研究首次为预测腹膜转移及今后的靶向治疗药物开发等提供了新的依据。

同时,此项成果还在第一时间申请了国家发明专利。它标志着对于胃癌腹膜转移的研究跨入精准医学时代。

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    2017-05-13 郝某

    我想说,文章都发表了,还可以申请专利吗?

    0

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    2015-12-30 xyfg98

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=197512, encodeId=ea5919e51277, content=我想说,文章都发表了,还可以申请专利吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJZib3flW42Q2olImgk28jLYqXFTL8lswKibDLMUbDgicdUStlvFhzCvu41hPJhU2IKLGOB3OBKs4Ribg/132, createdBy=86921932726, createdName=郝某, createdTime=Sat May 13 10:17:57 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661478, encodeId=4c9916614e8ea, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Mon Jun 27 07:06:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746027, encodeId=0abc1e460273c, content=<a href='/topic/show?id=6ce1e50024b' target=_blank style='color:#2F92EE;'>#科研人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75002, encryptionId=6ce1e50024b, topicName=科研人员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=064535650230, createdName=zhangj7120, createdTime=Thu May 12 00:06:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50396, encodeId=de9d50396f4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:45:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809273, encodeId=f11218092e34f, content=<a href='/topic/show?id=0c7983245d9' target=_blank style='color:#2F92EE;'>#胃癌腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83245, encryptionId=0c7983245d9, topicName=胃癌腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2500074, createdName=124987e8m07暂无昵称, createdTime=Sat Nov 28 12:06:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578989, encodeId=21aa15e8989b2, content=<a href='/topic/show?id=0ff4856621f' target=_blank style='color:#2F92EE;'>#腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85662, encryptionId=0ff4856621f, topicName=腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e6d16475304, createdName=新生儿张玉军, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623741, encodeId=b4041623e412b, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41910, encodeId=6e714191017, content=胃癌腹膜转移一直是治疗难点。如果能早期预防那当然很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Thu Oct 29 23:29:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41876, encodeId=0905418e6f6, content=去查下看看,这个杂志很纠结啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Oct 29 12:16:00 CST 2015, time=2015-10-29, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=197512, encodeId=ea5919e51277, content=我想说,文章都发表了,还可以申请专利吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJZib3flW42Q2olImgk28jLYqXFTL8lswKibDLMUbDgicdUStlvFhzCvu41hPJhU2IKLGOB3OBKs4Ribg/132, createdBy=86921932726, createdName=郝某, createdTime=Sat May 13 10:17:57 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661478, encodeId=4c9916614e8ea, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Mon Jun 27 07:06:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746027, encodeId=0abc1e460273c, content=<a href='/topic/show?id=6ce1e50024b' target=_blank style='color:#2F92EE;'>#科研人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75002, encryptionId=6ce1e50024b, topicName=科研人员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=064535650230, createdName=zhangj7120, createdTime=Thu May 12 00:06:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50396, encodeId=de9d50396f4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:45:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809273, encodeId=f11218092e34f, content=<a href='/topic/show?id=0c7983245d9' target=_blank style='color:#2F92EE;'>#胃癌腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83245, encryptionId=0c7983245d9, topicName=胃癌腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2500074, createdName=124987e8m07暂无昵称, createdTime=Sat Nov 28 12:06:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578989, encodeId=21aa15e8989b2, content=<a href='/topic/show?id=0ff4856621f' target=_blank style='color:#2F92EE;'>#腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85662, encryptionId=0ff4856621f, topicName=腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e6d16475304, createdName=新生儿张玉军, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623741, encodeId=b4041623e412b, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41910, encodeId=6e714191017, content=胃癌腹膜转移一直是治疗难点。如果能早期预防那当然很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Thu Oct 29 23:29:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41876, encodeId=0905418e6f6, content=去查下看看,这个杂志很纠结啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Oct 29 12:16:00 CST 2015, time=2015-10-29, status=1, ipAttribution=)]
    2015-10-31 xuyong530
  8. [GetPortalCommentsPageByObjectIdResponse(id=197512, encodeId=ea5919e51277, content=我想说,文章都发表了,还可以申请专利吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJZib3flW42Q2olImgk28jLYqXFTL8lswKibDLMUbDgicdUStlvFhzCvu41hPJhU2IKLGOB3OBKs4Ribg/132, createdBy=86921932726, createdName=郝某, createdTime=Sat May 13 10:17:57 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661478, encodeId=4c9916614e8ea, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Mon Jun 27 07:06:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746027, encodeId=0abc1e460273c, content=<a href='/topic/show?id=6ce1e50024b' target=_blank style='color:#2F92EE;'>#科研人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75002, encryptionId=6ce1e50024b, topicName=科研人员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=064535650230, createdName=zhangj7120, createdTime=Thu May 12 00:06:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50396, encodeId=de9d50396f4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:45:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809273, encodeId=f11218092e34f, content=<a href='/topic/show?id=0c7983245d9' target=_blank style='color:#2F92EE;'>#胃癌腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83245, encryptionId=0c7983245d9, topicName=胃癌腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2500074, createdName=124987e8m07暂无昵称, createdTime=Sat Nov 28 12:06:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578989, encodeId=21aa15e8989b2, content=<a href='/topic/show?id=0ff4856621f' target=_blank style='color:#2F92EE;'>#腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85662, encryptionId=0ff4856621f, topicName=腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e6d16475304, createdName=新生儿张玉军, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623741, encodeId=b4041623e412b, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41910, encodeId=6e714191017, content=胃癌腹膜转移一直是治疗难点。如果能早期预防那当然很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Thu Oct 29 23:29:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41876, encodeId=0905418e6f6, content=去查下看看,这个杂志很纠结啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Oct 29 12:16:00 CST 2015, time=2015-10-29, status=1, ipAttribution=)]
    2015-10-29 jetleo

    胃癌腹膜转移一直是治疗难点。如果能早期预防那当然很好

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=197512, encodeId=ea5919e51277, content=我想说,文章都发表了,还可以申请专利吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJZib3flW42Q2olImgk28jLYqXFTL8lswKibDLMUbDgicdUStlvFhzCvu41hPJhU2IKLGOB3OBKs4Ribg/132, createdBy=86921932726, createdName=郝某, createdTime=Sat May 13 10:17:57 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661478, encodeId=4c9916614e8ea, content=<a href='/topic/show?id=34a110150800' target=_blank style='color:#2F92EE;'>#驱动基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101508, encryptionId=34a110150800, topicName=驱动基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b94625296381, createdName=751943081_32627957, createdTime=Mon Jun 27 07:06:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746027, encodeId=0abc1e460273c, content=<a href='/topic/show?id=6ce1e50024b' target=_blank style='color:#2F92EE;'>#科研人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75002, encryptionId=6ce1e50024b, topicName=科研人员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=064535650230, createdName=zhangj7120, createdTime=Thu May 12 00:06:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50396, encodeId=de9d50396f4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:45:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809273, encodeId=f11218092e34f, content=<a href='/topic/show?id=0c7983245d9' target=_blank style='color:#2F92EE;'>#胃癌腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83245, encryptionId=0c7983245d9, topicName=胃癌腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2500074, createdName=124987e8m07暂无昵称, createdTime=Sat Nov 28 12:06:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578989, encodeId=21aa15e8989b2, content=<a href='/topic/show?id=0ff4856621f' target=_blank style='color:#2F92EE;'>#腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85662, encryptionId=0ff4856621f, topicName=腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e6d16475304, createdName=新生儿张玉军, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623741, encodeId=b4041623e412b, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sat Oct 31 00:06:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41910, encodeId=6e714191017, content=胃癌腹膜转移一直是治疗难点。如果能早期预防那当然很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Thu Oct 29 23:29:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41876, encodeId=0905418e6f6, content=去查下看看,这个杂志很纠结啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Oct 29 12:16:00 CST 2015, time=2015-10-29, status=1, ipAttribution=)]
    2015-10-29 gzhjjx

    去查下看看,这个杂志很纠结啊。

    0

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