J Paediatr:孕妈早期血糖高可能导致宝宝心脏发育缺陷!

2017-12-17 sunshine2015译自 medicalxpress 来宝网

根据斯坦福大学医学院的研究人员的研究,即使在无糖尿病的母亲身上,妊娠早期血糖升高也会增加婴儿患先天性心脏病的风险。

根据斯坦福大学医学院的研究人员的研究,即使在无糖尿病的母亲身上,妊娠早期血糖升高也会增加婴儿患先天性心脏病的风险。

该研究将于12月15日在“儿科学杂志”上发表。

多年来,医生们已经知道糖尿病妇女面临生育心脏缺陷婴儿的风险增加。一些研究也表明非糖尿病母亲的血糖水平与婴儿心脏缺陷风险之间存在联系。然而,这项新研究是第一个在妊娠早期胎儿心脏形成的时候研究这个问题的。

该研究的资深作者,儿科心脏病学助理教授James Priest博士说:“大多数患有先天性心脏病小孩的母亲不是糖尿病患者。 “我们发现,在尚未患有糖尿病或怀孕期间患有糖尿病的女性中,我们仍然可以通过在怀孕的头三个月期间查看他们的葡萄糖值来衡量患有先天性心脏病的孩子的风险。”

该研究的主要作者是儿科心脏病学的前身,前博士后学者Emmi Helle博士。

一个研究挑战

与开展研究相关的一个挑战是事实是,在非糖尿病孕妇中不常规测量母体血糖。相反,妇女通常在妊娠中途接受口服葡萄糖耐量试验,以确定其是否患有妊娠糖尿病,但是这种试验在胎儿心脏形成后进行。

该研究小组研究了2009年至2015年期间出生的19,107对母亲及其婴儿的病历。记录包括母亲的产前保健细节,包括血液检查结果以及任何在怀孕期间或出生后为婴儿进行的心脏诊断。没有包括某些遗传疾病的婴儿,多胎妊娠的婴儿以及母体极低或高体重指标的婴儿。在研究的婴儿中,有811人被诊断为先天性心脏病,其余的18296人没有。

科学家们分析了妊娠早期前四周和妊娠第一个三周刚刚结束时,从母亲收集的任何血液样本的血糖水平。这些早期的血糖测量可用于研究中的2,292或13%的女性。研究人员还观察了妊娠20周左右进行的口服葡萄糖耐量试验的结果,研究中有9511名女性,或不到一半的女性。

当风险升高时

排除怀孕前患糖尿病的妇女或怀孕期间患有糖尿病的妇女后,结果显示,生育先天性心脏病患儿的风险增加了8%。

这项研究的下一步是进行一项前瞻性研究,通过怀孕后的大批妇女,看看结果是否得到证实,牧师说。如果研究人员看到同样的关系,那么在妊娠早期测定所有孕妇的血糖可能是有帮助的,以帮助确定哪些患有心脏缺陷的婴儿更有风险。

Priest说:“我们可以使用血糖信息来选择筛查胎儿心脏的妇女,”他补充说,现代产前成像可以在出生前对许多先天性心脏缺陷进行详细的诊断。“了解产前缺陷可以改善结果,因为母亲可以接受专门护理,增加宝宝出生后更健康的机会。”

这项工作就是斯坦福大学精准健康专业的一个范例,其目标是预测和预防疾病的健康,准确地诊断和治疗疾病。

原始出处:Emmi I.T. Helle, Preston Biegley, Joshua W. Knowles,  et al. First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. The Journal of Pediatrics(2017) 

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    2018-01-05 jyzxjiangqin

    孕妇早期血糖管理.

    0

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[GetPortalCommentsPageByObjectIdResponse(id=1638255, encodeId=3fd31638255ae, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 01 06:03:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275661, encodeId=46b02e5661b6, content=孕妇早期血糖管理., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 05 10:00:12 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709356, encodeId=0b0b1e09356cb, content=<a href='/topic/show?id=8e92514549c' target=_blank style='color:#2F92EE;'>#心脏发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51454, encryptionId=8e92514549c, topicName=心脏发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Sep 13 12:03:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272020, encodeId=2af22e202034, content=孕妇早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Dec 24 07:26:05 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270822, encodeId=cffb2e0822d3, content=孕妈早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 20 07:26:53 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270632, encodeId=fe322e063269, content=孕期血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Dec 19 13:03:36 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347249, encodeId=dc58134e249f8, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489831, encodeId=f09a148983163, content=<a href='/topic/show?id=bcd5204ea9' target=_blank style='color:#2F92EE;'>#AED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2047, encryptionId=bcd5204ea9, topicName=AED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0108610571, createdName=makuansheng, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249816, encodeId=7952124981621, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Sun Dec 17 15:03:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270096, encodeId=ffe32e009690, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 17 13:22:28 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-24 jyzxjiangqin

    孕妇早期血糖高的危害.

    0

  5. 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10:00:12 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709356, encodeId=0b0b1e09356cb, content=<a href='/topic/show?id=8e92514549c' target=_blank style='color:#2F92EE;'>#心脏发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51454, encryptionId=8e92514549c, topicName=心脏发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Sep 13 12:03:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272020, encodeId=2af22e202034, content=孕妇早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Dec 24 07:26:05 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270822, encodeId=cffb2e0822d3, content=孕妈早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 20 07:26:53 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270632, encodeId=fe322e063269, content=孕期血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Dec 19 13:03:36 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347249, encodeId=dc58134e249f8, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489831, encodeId=f09a148983163, content=<a href='/topic/show?id=bcd5204ea9' target=_blank style='color:#2F92EE;'>#AED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2047, encryptionId=bcd5204ea9, topicName=AED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0108610571, createdName=makuansheng, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249816, encodeId=7952124981621, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Sun Dec 17 15:03:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270096, encodeId=ffe32e009690, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 17 13:22:28 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-20 jyzxjiangqin

    孕妈早期血糖高的危害.

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1638255, encodeId=3fd31638255ae, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 01 06:03:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275661, encodeId=46b02e5661b6, content=孕妇早期血糖管理., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jan 05 10:00:12 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709356, encodeId=0b0b1e09356cb, content=<a href='/topic/show?id=8e92514549c' target=_blank style='color:#2F92EE;'>#心脏发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51454, encryptionId=8e92514549c, topicName=心脏发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Sep 13 12:03:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272020, encodeId=2af22e202034, content=孕妇早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Dec 24 07:26:05 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270822, encodeId=cffb2e0822d3, content=孕妈早期血糖高的危害., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 20 07:26:53 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270632, encodeId=fe322e063269, content=孕期血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Dec 19 13:03:36 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347249, encodeId=dc58134e249f8, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489831, encodeId=f09a148983163, content=<a href='/topic/show?id=bcd5204ea9' target=_blank style='color:#2F92EE;'>#AED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2047, encryptionId=bcd5204ea9, topicName=AED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0108610571, createdName=makuansheng, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249816, encodeId=7952124981621, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Sun Dec 17 15:03:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270096, encodeId=ffe32e009690, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 17 13:22:28 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-19 llaq

    孕期血糖控制

    0

  7. 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createdBy=e5461842402, createdName=llaq, createdTime=Tue Dec 19 13:03:36 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347249, encodeId=dc58134e249f8, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489831, encodeId=f09a148983163, content=<a href='/topic/show?id=bcd5204ea9' target=_blank style='color:#2F92EE;'>#AED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2047, encryptionId=bcd5204ea9, topicName=AED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0108610571, createdName=makuansheng, createdTime=Tue Dec 19 03:03:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249816, encodeId=7952124981621, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Sun Dec 17 15:03:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270096, encodeId=ffe32e009690, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 17 13:22:28 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-19 neurowu
  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 17 13:22:28 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-19 makuansheng
  9. 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    2017-12-17 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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