Gastric Cancer: 术前改良全身炎症评分胃癌患者术后预后的预测作用

2019-10-21 不详 MedSci原创

基于术前血清白蛋白(Alb)水平和淋巴细胞与单核细胞比率(LMR)的全身炎症评分(SIS)已被证明是某些肿瘤的新型预后评分模型。本项研究旨在探究SIS是否可在胃癌(GC)患者中的起到预测作用。

背景
基于术前血清白蛋白(Alb)水平和淋巴细胞与单核细胞比率(LMR)的全身炎症评分(SIS)已被证明是某些肿瘤的新型预后评分模型。本项研究旨在探究SIS是否可在癌(GC)患者中的起到预测作用。

方法
本项研究纳入2008年12月至2013年12月间行根治性切除术的GC患者。随时间变化的受试者工作特征分析(t-ROC),一致性指数(C-index)和AUC用于比较预后影响。

结果
本研究共纳入1786例行癌切除的GC患者。通过多因素分析,SIS不是独立的预后因素。但是,正常的Alb水平(≥40 g / l)和LMR≥3.4都仍然是GC的独立保护因素(P<0.05)。由于正常Alb组中LMR≥3.4和LMR <3.4的患者的生存率相似,因此我们将两个亚组合并以建立改良的SIS(mSIS)。多变量分析显示,mSIS是唯一重要的独立生物标志物(P<0.05)。在整个观察期内,mSIS的t-ROC曲线和C指数均优于SIS。此外,术后3年和5年,mSIS的AUC显着大于SIS的AUC(均P<0.05)。

结论
术前mSIS是GC患者术后生存的一种新颖,简单且有用的预后因素,可以用作术前危险分层过程的一部分,以改善对临床结果的预测。

原始出处:

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    2020-06-28 许安
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    2020-05-17 skhzy
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