Clinica Chimica Acta:是否有必要检测天冬氨酸转氨酶和每一种丙氨酸转氨酶来检查老年人的健康?

2020-06-24 MedSci原创 MedSci原创

本研究旨在为了评估是否需要天冬氨酸转氨酶(AST)来筛查显然健康的老年人肝功能。

本研究旨在为了评估是否需要天冬氨酸转氨酶(AST)来筛查显然健康的老年人肝功能。

基于中国老年人配对(≥65岁)2018年体检,研究人员推导出不测量的AST的比例,定义为AST 升高为> 40U/L。采用Pearson方法分析谷丙转氨酶(ALT)与谷草转氨酶(AST)的关系。采用受试者工作特性曲线分析评价ALT对AST异常的预测准确性。

本研究分析了52,857对谷丙转氨酶和谷草转氨酶。血清谷丙转氨酶(AST)与血清谷丙转氨酶(ALT)呈正相关,r = 0.81, p < 0.01。ALT预测AST阳性的ROC曲线为0.918。ALT的最佳阈值为28u /L,敏感性为82.6%,特异性为86.8%。在阈值时,少于0.7%的AST阳性受试者被遗漏,但约83%的AST检测被排除。

研究表明,在老年人健康检查中AST测试和ALT测试都是不必要的。据估计,84.5%的受试者不需要AST测试,每年可以节省大约8.15亿元人民币(1.15亿美元或1亿欧元)。

原始出处:

Guo-Ming Zhang,Gao-Ming Zhang,Is testing of aspartate aminotransferase necessary along with every alanine aminotransferase for health check in elderly individuals?

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