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BMB Rep：人羊膜来源间充质干细胞通过ERK1/2 MAPK信号通路诱导人脂肪干细胞的成骨和血管生成

2018-03-16 MedSci MedSci原创

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间充质干细胞（MSCs）在治疗骨缺损方面显示出巨大的潜力。人类脂肪干细胞（HASCs）是具有多谱系分化潜能的多能祖细胞。人羊膜来源的间充质干细胞（HAMSCs）能够促进MSCs的成骨分化。 在这项研究中，我们通过transwell共培养系统研究了HAMSCs对HASCs的影响。结果显示，HAMSCs可促进HASCs的增殖、成骨分化、血管生成潜能和脂联素（APN）分泌。此外，U0126是一种高选择性

间充质干细胞（MSCs）在治疗骨缺损方面显示出巨大的潜力。人类脂肪干细胞（HASCs）是具有多谱系分化潜能的多能祖细胞。人羊膜来源的间充质干细胞（HAMSCs）能够促进MSCs的成骨分化。

在这项研究中，我们通过transwell共培养系统研究了HAMSCs对HASCs的影响。结果显示，HAMSCs可促进HASCs的增殖、成骨分化、血管生成潜能和脂联素（APN）分泌。此外，U0126是一种高选择性细胞外信号调节激酶1/2（ERK1/2）丝裂原活化蛋白激酶（MAPK）信号通路抑制剂，可显著抑制HAMSCs的积极作用。

综上所述，该研究结果表明HAMSCs通过ERK1/2MAPK信号通路诱导HASCs中的骨再生。

原始出处：

Wang Y, Chen X, et al., Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway. BMB Rep. 2018 Feb 12. pii: 4075. [Epub ahead of print]

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    2019-02-26 lidong51

    #MAPK#

    0

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    2019-01-31 h.y200607_23674418

    #间充质干细#

    0

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    2018-12-05 chenlianhui

    #ERK#

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    2018-03-18 zhaojie88

    #成骨#

    0

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    2018-03-18 zhouqu_8

    #脂肪干细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1717892, encodeId=8e731e178927d, content=<a href='/topic/show?id=c95711284ca' target=_blank style='color:#2F92EE;'>#MAPK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11284, encryptionId=c95711284ca, topicName=MAPK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21d332479882, createdName=lidong51, createdTime=Tue Feb 26 06:06:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815305, encodeId=9be8181530554, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Thu Jan 31 13:06:00 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752102, encodeId=cd7d1e52102d6, content=<a href='/topic/show?id=735669505d' target=_blank style='color:#2F92EE;'>#ERK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6950, encryptionId=735669505d, topicName=ERK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e8a36466835, createdName=chenlianhui, createdTime=Wed Dec 05 13:06:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351689, encodeId=8c691351689d0, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Mar 18 09:06:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438996, encodeId=9bd81438996b4, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 18 09:06:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539666, encodeId=008915396668c, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Mar 18 09:06:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-18 智者为医08

    #信号通路#

    0