J Intern Med:NAFLD患者的肠促胰素作用和高血糖素血症研究

2016-09-29 Moon 译 MedSci原创

我们对组织学检查证实非酒精性脂肪肝病(NAFLD)的患者进行了评估,探究这些患者的肠促胰素作用是否受损,以及是否存在高血糖素血症。 研究纳入了四组按年龄、性别和BMI匹配的参与者:10例糖耐量正常的NAFLD患者、10例有2型糖尿病的NAFLD患者、8例有2型糖尿病但没有肝脏疾病的患者、10例对照参与者。所有参与者都接受了50g葡萄糖耐量试验(OGTT)和IIGI。我们确定了参与者在OGTT

我们对组织学检查证实非酒精性脂肪肝病(NAFLD)的患者进行了评估,探究这些患者的肠促胰素作用是否受损,以及是否存在高血糖素血症。 研究纳入了四组按年龄、性别和BMI匹配的参与者:10例糖耐量正常的NAFLD患者、10例有2型糖尿病的NAFLD患者、8例有2型糖尿病但没有肝脏疾病的患者、10例对照参与者。所有参与者都接受了50g葡萄糖耐量试验(OGTT)和IIGI。我们确定了参与者在OGTT和IIGI期间的肠促胰素作用和β细胞的分泌反应。 数据显示,与其余三组比较,对照组表现出较高的肠促胰岛素作用[55% (43–73%)](P < 0.001);糖耐量正常的NAFLD患者、有2型糖尿病的NAFLD患者、有2型糖尿病但没有肝脏疾病的患者,其肠促胰岛素作用分别为39% (44–71%)、20% (−5−50%)和2% (−8−6%)。 我们发现NAFLD患者存在空腹高血糖素血症(伴糖尿病 7.5 pmol L−1 (6.8–15 pmol/L);不伴糖尿病 7.5 pmol L−1 (5.0–8.0 pmol/L))。空腹胰高血糖素水平较低,但无肝脏疾病的2型糖尿病患者和对照

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    2017-03-11 lvygwyt2781
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    2016-10-11 1e0d99ddm02(暂无匿称)

    总结的很好!

    0

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    2016-10-11 1e0d99ddm02(暂无匿称)

    分享一下!

    0

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    2016-10-01 hbwxf
  6. [GetPortalCommentsPageByObjectIdResponse(id=1944914, encodeId=371e1944914f7, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Fri May 26 16:24:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083895, encodeId=61ce208389537, content=<a href='/topic/show?id=d3b820e32c' target=_blank style='color:#2F92EE;'>#AFLD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2073, encryptionId=d3b820e32c, topicName=AFLD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sat Mar 11 18:24:00 CST 2017, time=2017-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144694, encodeId=3d3e14469413, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 16:58:54 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144693, encodeId=e07c144693f8, content=分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 16:58:47 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261089, encodeId=af201261089f7, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Oct 01 07:24:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607134, encodeId=1b50160e13468, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 01 07:24:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137842, encodeId=152313e842c7, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Sep 29 23:43:14 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137841, encodeId=703f13e84144, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Sep 29 23:43:09 CST 2016, time=2016-09-29, status=1, ipAttribution=)]
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    2016-09-29 doctorJiangchao

    继续关注

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1944914, encodeId=371e1944914f7, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Fri May 26 16:24:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083895, encodeId=61ce208389537, content=<a href='/topic/show?id=d3b820e32c' target=_blank style='color:#2F92EE;'>#AFLD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2073, encryptionId=d3b820e32c, topicName=AFLD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sat Mar 11 18:24:00 CST 2017, time=2017-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144694, encodeId=3d3e14469413, content=总结的很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 16:58:54 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144693, encodeId=e07c144693f8, content=分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Oct 11 16:58:47 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261089, encodeId=af201261089f7, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Oct 01 07:24:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607134, encodeId=1b50160e13468, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 01 07:24:00 CST 2016, time=2016-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137842, encodeId=152313e842c7, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Sep 29 23:43:14 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137841, encodeId=703f13e84144, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Thu Sep 29 23:43:09 CST 2016, time=2016-09-29, status=1, ipAttribution=)]
    2016-09-29 doctorJiangchao

    继续学习

    0

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