Ann Oncol: 前列腺癌患者年龄相关的黄斑变性风险

2017-10-02 AlexYang MedSci原创

前列腺癌(PC)与增加的系统性的氧化胁迫和二氢睾酮水平相关,同样,之前也有报道表明了前列腺癌参与了年龄相关的黄斑变性(AMD)病理过程。最近,有研究人员进行了一项群体试验从而确定是否患有PC 的病人具有增加的AMD风险。研究人员从台湾地区纵向医疗保险数据库中搜集了1999年到2010年期间的数据资料。研究PC群体包括了22084名年龄不小于18岁且为首次诊断为PC的病人。对照组病人在年龄、职业和城

前列腺癌(PC)与增加的系统性的氧化胁迫和二氢睾酮水平相关,同样,之前也有报道表明了前列腺癌参与了年龄相关的黄斑变性(AMD)病理过程。最近,有研究人员进行了一项群体试验从而确定是否患有PC 的病人具有增加的AMD风险。

研究人员从台湾地区纵向医疗保险数据库中搜集了1999年到2010年期间的数据资料。研究PC群体包括了22084名年龄不小于18岁且为首次诊断为PC的病人。对照组病人在年龄、职业和城市化水平上与PC组比例为1:1。初始研究结果为AMD的发生率,是通过 Kaplan-Meier生存分析和比例风险模型来评估的。研究的平均跟踪调查时间(标准差)在PC组和非PC组长分别为4.69年(2.90年)和5.51年(2.82年)。PC组平均年龄为73.9岁,非PC组平均年龄为73.2岁,并且年龄大于65岁的人数所占比例均约为85.9%。研究发现,与倾向分值匹配的非PC组相比,PC组具有更高的AMD风险,且调整后风险比为1.25(95%置信区间, 1.12-1.39)。与PC组且没有接受激素注射治疗的病人相比,接受激素注射治疗的PC组病人患AMD风险较低(调节后风险比,0.56;95%置信区间,0.41-0.76)。

最后,研究人员指出,PC与AMD风险的增加相关。患有PC且接受雄激素阻断注射形式治疗的病人AMD风险要比患有PC且没有接受雄激素阻断注射形式治疗病人更低。

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    2018-06-21 minlingfeng
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    2017-10-04 huangdf
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    2017-10-04 muzishouyi
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    2017-10-02 hhh678

    henhao

    0

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