Int J Impot Res:多巴胺基因多态性与早泄病人对帕罗西汀和依他普伦响应关系的研究

2017-09-17 AlexYang MedSci原创

最近,有研究人员评估了终生早泄(LPE)病人中,多巴胺(DA)转运基因的多态性和它在对帕罗西汀和依他普伦响应中的角色。研究招募了80名连续病人和对照。其中,有60名遭受LPE。研究人员将他们分成两个相等的小组。其中一个小组接受20mg每天的帕罗西汀,并持续3个月,另一个小组接受20mg每天的依他普伦,同样持续3个月。研究人员还邀请他们的妻子利用码表来对阴道内射精等待时间进行了测量。另外,研究人员还

最近,有研究人员评估了终生早泄(LPE)病人中,多巴胺(DA)转运基因的多态性和它在对帕罗西汀和依他普伦响应中的角色。研究招募了80名连续病人和对照。其中,有60名遭受LPE。研究人员将他们分成两个相等的小组。其中一个小组接受20mg每天的帕罗西汀,并持续3个月,另一个小组接受20mg每天的依他普伦,同样持续3个月。研究人员还邀请他们的妻子利用码表来对阴道内射精等待时间进行了测量。另外,研究人员还对患者和对照进行了5毫升血液的抽取和PCR分析。研究发现,患者的平均年龄为41.42岁,对照组平均年龄为36.4岁。大多数病人DA转运基因多态性的基因型为(10R/10R),然而,对照组基因型为6R/6R,并且具有统计学上的显著性(p=0.001)。另外,帕罗西汀和依他普伦显著的推迟了射精时间(p=0.001和p=0.001)。最后,研究人员指出,该研究阐释了DA转运基因多态性与响应之间显著的关系(倍数增加和log FI显著性分别为p=0.019和0.010)。另外,研究人员还表明了该研究是首次报道并阐释了在LPE病人中DA转运基因多态性与响应之间具有高度的显著相关性。原始出处:T K Elt

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    2017-09-20 lucycici

    学习一下

    0

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  4. 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objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Tue Sep 19 07:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629231, encodeId=72f0162923169, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Tue Sep 19 07:54:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245340, encodeId=09852453409c, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon Sep 18 14:17:24 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245106, encodeId=7a03245106c6, content=研究人员还表明了该研究是首次报道并阐释了在LPE病人中DA转运基因多态性与响应之间具有高度的显著相关性., beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Sep 17 22:37:57 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245102, encodeId=0d972451028a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Sun Sep 17 22:16:57 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245099, encodeId=50cd24509912, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-19 风铃826
  5. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-19 xzw120
  6. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-18 执着追梦

    学习.谢谢分享

    0

  7. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 有备才能无患

    研究人员还表明了该研究是首次报道并阐释了在LPE病人中DA转运基因多态性与响应之间具有高度的显著相关性.

    0

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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 方舒

    学习

    0

  9. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 17 22:12:47 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245050, encodeId=39a7245050dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Sep 17 17:01:21 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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