Transplantation:缬沙坦通过改善肾klotho表达和氧化性应激减缓环孢素性肾中毒

2017-06-27 MedSci MedSci原创

免疫抑制药物环孢素A(CsA)的副作用会引起中毒性肾损伤,它可能是移植药物存在的主要问题。环孢素A引起的肾中毒是多因素的作用过程,但氧化性应激是其中的一个主要因素。研究发现,缬沙坦(Val)作为血管紧张素受体阻断剂具有保护肾脏的作用,但是其独立于降压作用以外的肾保护功能的分子机制还不完全清楚。这篇研究的目的是为了阐明Val是否通过增强肾内klotho表达或/和减轻氧化性应激进而减缓CsA引发的中毒

免疫抑制药物环孢素A(CsA)的副作用会引起中毒性肾损伤,它可能是移植药物存在的主要问题。环孢素A引起的肾中毒是多因素的作用过程,但氧化性应激是其中的一个主要因素。研究发现,缬沙坦(Val)作为血管紧张素受体阻断剂具有保护肾脏的作用,但是其独立于降压作用以外的肾保护功能的分子机制还不完全清楚。这篇研究的目的是为了阐明Val是否通过增强肾内klotho表达或/和减轻氧化性应激进而减缓CsA引发的中毒性肾损伤。

研究使用32只Sprague-Dawley大鼠,并按照施加CsA或/和Val的不同分为4组:组A (对照, 每日1 mL/kg的橄榄油作为载体), 组B (CsA, 每日30 mg/kg), 组C (CsA + Val, 每日30 + 30 mg/kg), 和组D (Val, 每日30 mg/kg)。实时聚合酶链式反应和Western blot检测肾内klotho表达情况。血清klotho表达水平通过酶联免疫吸附测定进行检测。另外,通过酶联免疫吸附测定和光谱光度测量法分别检测氧化性应激标志物8-羟基脱氧鸟苷和丙二醛表达水平变化。

结果显示,施加环孢素A刺激会减少肾内及血清中klotho表达,上调8-羟基脱氧鸟苷和丙二醛表达水平,并同时损伤肾脏功能。缬沙坦可以阻碍CsA诱导的氧化性应激,改善klotho的表达下调,减缓CsA诱导的肾组织学改变及肾功损伤。

结论:缬沙坦可能是通过减缓环孢素A诱导的klotho表达下调和氧化性应激来改善环孢素A引发的中毒性肾损伤。

原始出处

Raeisi S, Ghorbanihaghjo A, et al. The Effects of Valsartan on Renal Klotho Expression and Oxidative Stress in Alleviation of Cyclosporine Nephrotoxicity. Transplantation. 2017 Jun 23. doi: 10.1097/TP.0000000000001350.

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    2018-03-25 syscxl
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    2017-07-25 bsmagic9140
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likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo61WAV0ROeLAoicPxPKoKaogwLWLL8STv86qplbdOibN2YR4KxkJicqNectCXGR8gPJhGLc7yYLSdnpx4kaVXndTfu/0, createdBy=a6962042337, createdName=1391e9f2a7m, createdTime=Sun Jul 02 07:08:57 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216684, encodeId=520921668417, content=文章不错啊,我很受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 29 14:26:04 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319039, encodeId=69ba131903987, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407819, encodeId=8cdd140e819b2, content=<a href='/topic/show?id=ab471053548' target=_blank style='color:#2F92EE;'>#Klotho#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10535, encryptionId=ab471053548, topicName=Klotho)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367664, encodeId=6ef1136e6646a, content=<a href='/topic/show?id=9334e9305c7' target=_blank style='color:#2F92EE;'>#缬沙坦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79305, encryptionId=9334e9305c7, topicName=缬沙坦)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-08-15 xuyu
  5. 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  6. 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likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo61WAV0ROeLAoicPxPKoKaogwLWLL8STv86qplbdOibN2YR4KxkJicqNectCXGR8gPJhGLc7yYLSdnpx4kaVXndTfu/0, createdBy=a6962042337, createdName=1391e9f2a7m, createdTime=Sun Jul 02 07:08:57 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216684, encodeId=520921668417, content=文章不错啊,我很受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Jun 29 14:26:04 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319039, encodeId=69ba131903987, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, 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encodeId=6ef1136e6646a, content=<a href='/topic/show?id=9334e9305c7' target=_blank style='color:#2F92EE;'>#缬沙坦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79305, encryptionId=9334e9305c7, topicName=缬沙坦)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-07-02 1391e9f2a7m

    很好的文章,值得分享

    0

  7. 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encodeId=6ef1136e6646a, content=<a href='/topic/show?id=9334e9305c7' target=_blank style='color:#2F92EE;'>#缬沙坦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79305, encryptionId=9334e9305c7, topicName=缬沙坦)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-06-29 1e1b8538m79(暂无匿称)

    文章不错啊,我很受用

    0

  8. 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encodeId=6ef1136e6646a, content=<a href='/topic/show?id=9334e9305c7' target=_blank style='color:#2F92EE;'>#缬沙坦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79305, encryptionId=9334e9305c7, topicName=缬沙坦)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Thu Jun 29 12:44:00 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-06-29 mashirong
  9. 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