Brit J Cancer:癌症家族史、犹太血统与胰腺癌风险

2019-03-15 xing.T 网络

由此可见,胰腺癌家族史与这种恶性肿瘤的风险增加有关。乳腺癌或结直肠癌家族史与AJ男性风险增加有关。

有癌症家族史的个体可能患胰腺癌的风险增加。阿什肯纳兹犹太人(AJ)患胰腺癌和其他癌症类型的风险增加。

近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员评估了前瞻性卫生专业人员随访研究的49410名男性参与者的癌症家族史和AJ遗传与胰腺癌事件之间的关联,并使用多变量调整的Cox比例风险模型估算风险比(HRs)。

在110万人次每年随访期间(1986-2016),452名参与者患上了胰腺癌。在有胰腺家族史(HR为2.79; 95%置信区间[CI]为1.28-6.07)或乳腺癌(HR为1.40; 95%CI为1.01-1.94)的个体中观察到胰腺癌风险增加。与直肠癌家族史(HR为1.21; 95%CI为0.95-1.55)或AJ遗传(HR为1.29; 95%CI为0.94-1.77)相比,存在胰腺癌风险增加的趋势。有乳腺癌或直肠癌家族史的男性患者风险增加(HR分别为2.61[95%CI为1.41-4.82]和1.92[95%CI为1.05-3.49])。

由此可见,胰腺癌家族史与这种恶性肿瘤的风险增加有关。乳腺癌或结直肠癌家族史与AJ男性风险增加有关。

原始出处:

Tsuyoshi Hamada,et al.Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk.British Journal of Cancer. 2019.https://www.nature.com/articles/s41416-019-0426-5

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    2019-08-12 sjq027
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