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Oncotarget：RUNX2调节癌症中人参皂甙Rg1诱导的血管发生

2017-08-10 Emma MedSci原创

人参皂甙Rg1Runx2miR-23a
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人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。有趣的是，Rg1的功能在癌细胞和内皮细胞中是相对独立但是不同的。

人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。有趣的是，Rg1的功能在癌细胞和内皮细胞中是相对独立但是不同的。Rg1与血管生成因子和细胞外基质成分有很多复杂的相互作用，其有利于血管生成，如诱导内皮细胞中促血管生成因子VEGF-A（血管内皮生长因子）的表达，而内皮细胞中的血管生成功能促进癌症的发展。RUNX2（Runt相关转录因子2）是属于RUNX家族的转录因子，在成骨细胞分化中起关键作用，也被认为是在肿瘤中发现的间充质干细胞的标志物，参与涉及癌症生长进程的各种信号通路，其在血管生成中的作用尚不清楚。

发表于Oncotarget的一篇文章中，研究人员首次报道RUNX2为人参皂苷Rg1诱导的血管发生调节因子。他们发现RUNX2被miR-23a直接靶向和调控，miR-23a显示出抑制HUVECs（人脐静脉内皮细胞）和斑马鱼中的血管生成的作用。RUNX2表达降低会导致VEGF-A在HUVEC中的翻译受到抑制。该研究确定了血管生成中的MiR-23a/RUNX2/VEGF-A途径，并阐明了Rg1诱导血管生成的分子机制。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。

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    2018-02-23 柳叶一刀

    #血管发生#

    0

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    2018-06-22 仁医06

    #target#

    0

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    2017-08-15 stfoxst

    #Runx2#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1976521, encodeId=4a2e19e652126, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Feb 23 14:44:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795431, encodeId=d1d91e954311e, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jun 22 03:44:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669005, encodeId=90861669005c0, content=<a href='/topic/show?id=f4c915e4262' target=_blank style='color:#2F92EE;'>#Runx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15742, encryptionId=f4c915e4262, topicName=Runx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635226492904, createdName=stfoxst, createdTime=Tue Aug 15 16:44:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232996, encodeId=ba6923299620, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Aug 13 00:58:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232570, encodeId=3e142325e091, content=g1诱导血管生成。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:36:30 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232569, encodeId=f47723256941, content=人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:35:36 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232537, encodeId=db0b23253edb, content=好好努力看下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 11 19:49:17 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232321, encodeId=3df323232171, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Aug 11 06:09:55 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-13 luominglian113

    学习了，谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1976521, encodeId=4a2e19e652126, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Feb 23 14:44:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795431, encodeId=d1d91e954311e, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jun 22 03:44:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669005, encodeId=90861669005c0, content=<a href='/topic/show?id=f4c915e4262' target=_blank style='color:#2F92EE;'>#Runx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15742, encryptionId=f4c915e4262, topicName=Runx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635226492904, createdName=stfoxst, createdTime=Tue Aug 15 16:44:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232996, encodeId=ba6923299620, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Aug 13 00:58:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232570, encodeId=3e142325e091, content=g1诱导血管生成。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:36:30 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232569, encodeId=f47723256941, content=人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:35:36 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232537, encodeId=db0b23253edb, content=好好努力看下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 11 19:49:17 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232321, encodeId=3df323232171, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Aug 11 06:09:55 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-11 随梦飞扬

    g1诱导血管生成。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1976521, encodeId=4a2e19e652126, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Feb 23 14:44:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795431, encodeId=d1d91e954311e, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jun 22 03:44:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669005, encodeId=90861669005c0, content=<a href='/topic/show?id=f4c915e4262' target=_blank style='color:#2F92EE;'>#Runx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15742, encryptionId=f4c915e4262, topicName=Runx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635226492904, createdName=stfoxst, createdTime=Tue Aug 15 16:44:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232996, encodeId=ba6923299620, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Aug 13 00:58:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232570, encodeId=3e142325e091, content=g1诱导血管生成。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:36:30 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232569, encodeId=f47723256941, content=人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:35:36 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232537, encodeId=db0b23253edb, content=好好努力看下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 11 19:49:17 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232321, encodeId=3df323232171, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Aug 11 06:09:55 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-11 随梦飞扬

    人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。

    0

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    2017-08-11 虈亣靌

    好好努力看下吧

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1976521, encodeId=4a2e19e652126, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Feb 23 14:44:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795431, encodeId=d1d91e954311e, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jun 22 03:44:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669005, encodeId=90861669005c0, content=<a href='/topic/show?id=f4c915e4262' target=_blank style='color:#2F92EE;'>#Runx2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15742, encryptionId=f4c915e4262, topicName=Runx2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635226492904, createdName=stfoxst, createdTime=Tue Aug 15 16:44:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232996, encodeId=ba6923299620, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Aug 13 00:58:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232570, encodeId=3e142325e091, content=g1诱导血管生成。研究表明，RUNX2可能是癌症中Rg1诱导的血管发生的潜在治疗靶点。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:36:30 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232569, encodeId=f47723256941, content=人参皂甙Rg1为五加科植物人参的根，具有促进海马神经发生、抗疲劳、提高免疫力、辅助抗肿瘤等作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Fri Aug 11 21:35:36 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232537, encodeId=db0b23253edb, content=好好努力看下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Aug 11 19:49:17 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232321, encodeId=3df323232171, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Aug 11 06:09:55 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-11 三生有幸9135

    学习一下谢谢分享

    0