Br J Ophthalmo:抗逆转录病毒治疗后出现活跃的巨细胞病毒性视网膜炎

2018-09-19 MedSci MedSci原创

美国旧金山加州太平洋医疗中心眼科的Heiden D近日在Br J Ophthalmo杂志上发表了一篇文章,对艾滋病相关巨细胞病毒(CMV)视网膜炎患者进行抗逆转录病毒治疗后依然出现视网膜炎的案例进行分析讨论。

美国旧金山加州太平洋医疗中心眼科的Heiden D近日在Br J Ophthalmo杂志上发表了一篇文章,对艾滋病相关巨细胞病毒(CMV)视网膜炎患者进行抗逆转录病毒治疗后依然出现视网膜炎的案例进行分析讨论。

艾滋病相关巨细胞病毒(CMV)视网膜炎患者接受了联合抗逆转录病毒治疗(cART),但没有进行抗CMV的特异性治疗,出现了持续数月的视网膜炎。诊断的延迟和治疗CMV视网膜炎的延迟可能会产生严重的后果。

因此,他们建议,除了cART治疗之外,应首先通过扩张间接检眼镜立即筛查患有晚期HIV感染并且具有极大可能重新激活潜伏性CMV感染的患者,进行筛查CMV视网膜炎,并且立即使用特异性抗CMV治疗。

原文出处:

Heiden, D., et al., Active cytomegalovirus retinitis after the start of antiretroviral therapy. Br J Ophthalmol, 2018.

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objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94758, encryptionId=623294e587c, topicName=逆转录病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f67438, createdName=xiaogang317, createdTime=Tue Jan 29 06:43:00 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033606, encodeId=c0b5203360694, content=<a href='/topic/show?id=530f4821661' target=_blank style='color:#2F92EE;'>#巨细胞病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48216, encryptionId=530f4821661, topicName=巨细胞病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Thu Nov 01 13:43:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270111, encodeId=17a412e011133, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502229, encodeId=b7571502229dd, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541389, encodeId=c617154138961, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
    2018-12-09 howi
  5. 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  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541389, encodeId=c617154138961, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1926858, encodeId=5d8e192685854, content=<a href='/topic/show?id=09d594e5610' target=_blank style='color:#2F92EE;'>#逆转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94756, encryptionId=09d594e5610, topicName=逆转录)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Wed Mar 13 07:43:00 CST 2019, time=2019-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1747326, encodeId=1cbe1e47326c3, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541389, encodeId=c617154138961, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
    2018-09-21 zutt
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541389, encodeId=c617154138961, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Sep 21 12:43:00 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
    2018-09-21 wwzzly
  10. 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Etravirine是一种非核苷逆转录酶抑制剂,与其他抗逆转录病毒药联合用于治疗≥6岁的艾滋病毒患者。Etravirine主要由细胞色素P450(CYP)2C9,CYP2C19和CYP3A代谢。该分析确定了伴随的抗逆转录病毒药物和CYP2C9 / CYP2C19表型对Etravirine的药代动力学的影响。

AIM:维生素D和钙抑制开始抗逆转录病毒治疗时的骨密度损失

背景:HIV-1感染的起始抗逆转录病毒治疗与骨密度(BMD)损失2%到6%相关。    意义:评估维生素D3加钙的补充对起始抗逆转录病毒治疗相关的骨损失的影响。    设计:48周的前瞻性、随机、双盲、安慰剂对照研究。包括39个艾滋病临床试验组单位。参与者为使用抗逆转录病毒治疗的感染HIV的成人患者。    

降低HIV感染率,只有割包皮?

前言:世界卫生组织正不遗余力的呼吁、推广包皮环切以降低HIV感染率。面对HIV,人类知道的难道只有包皮环切手术吗?非洲大陆的莫桑比克已进入夏天,烈日下,一群少年打闹着排着队,在流动诊所的帐篷外等待着进行包皮环切手术(Circumcision)。15岁的Helio(赫利奥)正在队伍里和他的小伙伴们打着扑克。一年前,他的朋友死于HIV感染,才19岁。之后,惊恐的Helio央求祖父能让他做环切手术。

JAMA:2016国际抗病毒协会美国分会:成人HIV感染抗病毒药物治疗和预防共识

对于抗逆转录病毒药物(ARVs)的使用建议需要更新新的数据和治疗方案以治疗或预防成年人感染艾滋病毒。本研究旨在为感染HIV的成年人(年龄≥18年)提供最新的抗逆转录病毒治疗方法,包括何时开始治疗,初始治疗方案,改变方案,以及使用抗逆转录病毒药物预防高危人群感染HIV,包括暴露前和暴露后的预防。国际抗病毒协会召开了会议,HIV研究和病人护理的专家小组审查了2014年以来发表在同行评审期刊上的新的研究

世卫组织将修改抗艾指导方针

世界卫生组织(WHO)日前表示,它将建议每一个艾滋病病毒(HIV)感染者在诊断后应尽早使用抗逆转录病毒(ARV)药物进行治疗—— 一系列令人信服的试验已经证明了早期治疗的益处。该组织在加拿大温哥华召开的国际艾滋病(AIDS)协会(IAS)年会的一场卫星会议上,讨论了被广泛预期的改变其现有指导方针的计划,与此同时,研究人员还在此次IAS年会上公布了来自ARV治疗试验的鼓舞人心的最新结果。WHO下属H

Pediatr Infect Dis J:孕期抗逆转录病毒治疗与小于胎龄儿

世界上每天大约有1500名儿童感染艾滋病毒,其中大部分是在母亲怀孕和分娩时被感染的新生胎儿。通常HIV孕妇可以使用抗逆转录病毒(ARV)治疗以最大限度的减少垂直传播风险。先前有研究报道孕期抗逆转录病毒(ARV)治疗和小于胎龄儿(SGA)间有着某种关系,但目前的报道均不能完全阐明该联系。因此Phiri K等人收集了田纳西州相关医学记录,纳入1994-2009年间HIV孕妇。根据诊断、ARV处方、CD