Eur Heart J.:缺血性卒中患者血压与住院期间预后的关系研究。

2017-10-10 fengxiangxin MedSci原创

卒中后高血压与短期预后差有关,但结果是相互矛盾的。本研究中,研究者的目标是评估急性缺血性卒中患者血压与住院期间预后的关系。

卒中高血压与短期预后差有关,但结果是相互矛盾的。本研究中,研究者的目标是评估急性缺血性卒中患者血压与住院期间预后的关系。

在中风准则依循计划(Get With The Guidelines-Stroke )中登记了急性缺血性卒中的患者被纳入本研究。入院时的收缩压和舒张压用于计算平均动脉压(MAP)和脉压(PP)。研究者观察的结果是:住院期间的死亡率、未出院回家、出院后不能独立走动和溶栓治疗后的出血并发症。

共309611例缺血性卒中患者被纳入本研究。收缩压和结果之间出现了J形或U形关系:与中心参考值相比,较低和较高的收缩压值均与住院期间更高的死亡风险相关[120 vs 150mmHg:调整后的比值比(95%置信区间)(OR[CI])=1.16[1.13-1.20] ;200 vs 150mmHg:1.24[1.19-1.30]],未出院回家(120 vs 150mmHg :OR[CI]=1.11[1.09-1.13] ;200 vs 150mmHg:1.15[1.12-1.18]),出院不能独立行走(120 vs 150mmHg:OR[CI]=1.16[1.13-1.18] ;200 vs 150mmHg :1.09[1.06-1.11]  )。

然而,较低的收缩压溶栓治疗后的出血并发症风险较低(120 vs 150mmHg:OR[CI]=0.89[0.83-0.97]),较高的收缩压溶栓治疗后的出血并发症风险较高(200 vs 150mmHg:OR[CI]=1.21[1.11-1.32])。

本研究结论是:缺血性脑卒中住院患者中,在BP变化和住院期间的预后出现了J形或U形关系。拥有较低血压的患者在溶栓治疗后出血并发症风险较低。

原始出处:

Bangalore S, Schwamm L, Smith EE.et al.Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke.Eur Heart J.2017 Oct 1;38(37):2827-2835. doi: 10.1093/eurheartj/ehx330.

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    2017-10-12 zhaojie88
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    2017-10-12 slcumt

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