Epidemiology:孕期饮用水中砷浓度影响宝宝出生体重

2015-11-20 Mechront 译 MedSci原创

目前关于孕期砷暴露和新生儿出生体重的关系并不明确。研究者进行了一项研究,评估产前砷暴露和出生体重之间的因果关系,考虑到孕龄和产妇在怀孕期间体重增加等因素对新生儿出生体重的潜在影响,研究者使用结构方程模型(SEMs)对数据进行分析。该前瞻性研究纳入了2008-2011年孟加拉国的孕妇。在纳入研究时对1140名孕周小于16周的孕妇检测去饮用水里砷浓度,产后1个月内对624名产妇检测脚趾甲里砷含量。使用

目前关于孕期砷暴露和新生儿出生体重的关系并不明确。研究者进行了一项研究,评估产前砷暴露和出生体重之间的因果关系,考虑到孕龄和产妇在怀孕期间体重增加等因素对新生儿出生体重的潜在影响,研究者使用结构方程模型(SEMs)对数据进行分析。

该前瞻性研究纳入了2008-2011年孟加拉国的孕妇。在纳入研究时对1140名孕周小于16周的孕妇检测饮用水里砷浓度,产后1个月内对624名产妇检测脚趾甲里砷含量。使用SEMs估计砷暴露对新生儿出生体重的直接和间接影响,其中孕龄和产妇在怀孕期间体重增加作为中介变量。

研究结果显示,校正其他混杂因素后,水中砷含量每增加一个自然对数单位,与新生儿出生体重的下降间接相关 (β=-19.17 g, 95% CI: -24.64, -13.69);孕龄与出生体重的关系:β=-17.37 g, 95% CI: -22.77, -11.98;产妇孕期体重增长与出生体重的关系:β=-1.80 g, 95% CI: -3.72, 0.13。用脚趾甲中砷浓度建模时,得到相似结果。脚趾甲中砷浓度每增加一个自然对数单位,与新生儿出生体重的下降间接相关(β=-13.59 g, 95% CI: -22.10, -5.07);产妇孕期体重增长与出生体重的关系:β=-2.13 g, 95% CI: -5.24, 0.96。

研究结果显示,孕期砷暴露可降低新生儿出生体重。两者之间的关系似乎是通过降低孕周、一定程度上降低产妇孕期体重增长而相关。

原始出处:

Kile ML, Cardenas A,et al.Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort.Epidemiology. 2015 Nov 18.


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    2015-11-22 lishizhe
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