J Pain Res:丙泊酚麻醉与七氟醚麻醉对根治性胃切除术后疼痛影响的比较:随机对照试验

2018-08-12 李华宇 罂粟花

根治性胃切除术后的患者术后可能会出现剧烈疼痛。有研究表明,丙泊酚的使用可显著减轻患者术后疼痛,而有人则认为这种效果并不明显。因此,本研究的目的是探讨丙泊酚是否有助于减轻开放性胃癌根治术后患者的疼痛。

目 的

根治性胃切除术后的患者术后可能会出现剧烈疼痛。有研究表明,丙泊酚的使用可显着减轻患者术后疼痛,而有人则认为这种效果并不明显。因此,本研究的目的是探讨丙泊酚是否有助于减轻开放性胃癌根治术后患者的疼痛。

方 法

将行开放性根治性胃切除术的60名择期患者随机分为丙泊酚组或七氟醚组(每组n = 30)。行靶控输注丙泊酚或吸入七氟醚,维持脑电双频指数为40-60。 所有患者均接受标准化的多模式镇痛计划,包括术中使用右美托咪定、地塞米松和术后使用氟比洛芬酯,以及使用芬太尼自控镇痛。记录患者血流动力学、疼痛评分、芬太尼用量、不良事件发生率以及出院后1个月和3个月后慢性疼痛的发生情况。

结 果

所有患者术后疼痛强度为低至中等。与七氟醚组相比,丙泊酚组术后48小时休息及咳嗽时疼痛评分均较低(P<0.05)。丙泊酚组术后0-24小时芬太尼用量较低(364.4±139.1 vs. 529.3±237.9μg; P = 0.002)。然而,对于0-48小时的芬太尼用量,两组之间差异无统计学意义(710.9±312.8对比850.9±292.0μg; P = 0.078)。各组间不良事件或慢性疼痛的发生率无差异无统计学意义。

结 论

综上所述,多模式镇痛方法减少了在使用丙泊酚或七氟醚麻醉下行开放式胃癌根治术患者的术后疼痛。此外,我们的结果表明丙泊酚组的镇痛效果更好,特别是在术后早期。

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    2018-08-14 bshuang
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    2018-08-14 jeanqiuqiu
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    2018-08-13 liumin1987

    谢谢分享,学习了。

    0

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