Diabetes Obes Metab:双醋瑞因在减少2型糖尿病合并非酒精性脂肪性肝病患者肝脂肪变性和纤维化的疗效

2019-02-04 xing.T MedSci原创

总之,采用双醋瑞因治疗2年可显著降低NAFLD合并糖尿病患者的肝脏纤维化程度。

近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,这项随机双盲安慰剂对照试验旨在评估双醋瑞因(一种抗炎药)在改善2型糖尿病和非酒精性脂肪性肝病(NAFLD)患者的肝纤维化和脂肪变性方面的功效。

研究人员将69名患有NAFLD的糖尿病患者随机分为安慰剂组(35名患者)或双醋瑞因组100mg/天(34名患者),治疗24个月。在基线、第12个月和第24个月随访时通过瞬时弹性成像(Fibroscan®)评估肝硬度和脂肪变性。主要结局是治疗期间平均肝硬度和脂肪变化的差异。研究人员通过广义重复测量混合效应回归估计意向治疗分析的平均变化的调整差异。

与安慰剂相比,双醋瑞因显著降低肝硬度1.6kPa(95%CI为-2.6至-0.5kPa; p=0.003),而肝脏脂肪变性的平均变化没有显著差异。在第12个月的检查中,肝硬度的降低已经很明显,并且在第24个月时更加明显。8名患者在治疗期间肝纤维化阶段减轻,在双醋瑞因组中有7名患者减轻(p=0.020)。

总之,采用双醋瑞因治疗2年可显著降低NAFLD合并糖尿病患者的肝脏纤维化程度。

原始出处:


Nathalie C. Leite,et al. Efficacy of Diacerein in Reducing Liver Steatosis and Fibrosis in Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: a Randomized, Placebo‐Controlled Trial.Diabetes Obesity & Metabolism.2019.https://onlinelibrary.wiley.com/doi/10.1111/dom.13643

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    2019-11-18 guojianrong
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time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902210, encodeId=fece1902210ea, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Aug 02 14:36:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
  5. 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  6. 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  7. 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time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902210, encodeId=fece1902210ea, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Aug 02 14:36:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
    2019-02-10 qjddjq
  8. 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time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902210, encodeId=fece1902210ea, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Aug 02 14:36:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
    2019-11-01 一闲
  9. 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