BMJ:氟喹诺酮类药物增加患者主动脉瘤或夹层风险

2018-03-12 zhangfan MedSci原创

研究认为口服氟喹诺酮类药物导致患者主动脉瘤或夹层风险增加

氟喹诺酮类药物抗菌药广泛用于泌尿生殖系统疾病、胃肠疾病,以及呼吸道、皮肤组织的革兰阴性细菌感染的治疗。近日研究人员通过全国性队列回顾研究,考察了口服氟喹诺酮类药物与主动脉瘤或夹层风险之间的相关性。

研究收集了360088人次使用氟喹诺酮类药物(78%环丙沙星)患者数据,同时倾向匹配了36088人次阿莫西林使用患者。采用COX回归分析评估患者主动脉瘤或夹层初次诊断的危险比,即药物治疗后60天内因主动脉瘤或夹层入院、急诊或死亡。

60天风险期内,氟喹诺酮类使用者每1000患者年主动脉瘤或夹层确诊1.2例,而阿莫西林组为0.7例,氟喹诺酮增加患者主动脉瘤或夹层风险(HR,1.66,95%,CI,1.12-2.46)。在100万的治疗人群中,60天风险期内,组间主动脉瘤或夹层发病差异为82例。二次风险显示,氟喹诺酮类药物导致主动脉瘤的风险比为1.90,导致主动脉壁夹层形成风险比为0.93。

研究认为口服氟喹诺酮类药物导致患者主动脉瘤或夹层风险增加。

原始出处:


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    2018-04-16 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Mar 28 06:07:07 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848481, encodeId=6b75184848174, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat May 12 15:58:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296815, encodeId=0bb8296815c8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Mar 16 14:26:03 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296444, encodeId=778129644477, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Mar 15 10:10:53 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415286, encodeId=32d01415286cb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Mar 14 00:58:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429032, encodeId=1a6b14290321c, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Wed Mar 14 00:58:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523099, encodeId=1bae15230994d, content=<a href='/topic/show?id=fe8663915a3' target=_blank style='color:#2F92EE;'>#氟喹诺酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63915, encryptionId=fe8663915a3, topicName=氟喹诺酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff0911497072, createdName=doctorzheng, createdTime=Wed Mar 14 00:58:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-28 一个字-牛

    学习了谢谢分享

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Mar 16 14:26:03 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296444, encodeId=778129644477, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Mar 15 10:10:53 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415286, encodeId=32d01415286cb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, 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encodeId=1bae15230994d, content=<a href='/topic/show?id=fe8663915a3' target=_blank style='color:#2F92EE;'>#氟喹诺酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63915, encryptionId=fe8663915a3, topicName=氟喹诺酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff0911497072, createdName=doctorzheng, createdTime=Wed Mar 14 00:58:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-05-12 gaoxiaoe
  6. 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encodeId=1bae15230994d, content=<a href='/topic/show?id=fe8663915a3' target=_blank style='color:#2F92EE;'>#氟喹诺酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63915, encryptionId=fe8663915a3, topicName=氟喹诺酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff0911497072, createdName=doctorzheng, createdTime=Wed Mar 14 00:58:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-16 一个字-牛

    学习了谢谢分享

    0

  7. 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    2018-03-15 虈亣靌

    了解一下.谢谢分享!

    0

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主动脉夹层,这一危急重症,是从无到有瞬间发生,还是像癌症那样有个进展过程的呢?

JAHA:2型糖尿病患者主动脉瘤和主动脉夹层的长期风险降低!

由此可见,与CS相比,T2DM患者AA和AD的风险显著降低,AA住院后死亡率也有所降低。数据表明主动脉组织中的糖化交联可能在T2DM患者主动脉病变进展中发挥保护作用。

Br J Surg:二甲双胍或能限制腹主动脉瘤生长

2017年10月,发表在《Br J Surg》的一项由澳大利亚和新西兰科学家进行的研究考察了二甲双胍与腹主动脉瘤(AAA)生长率之间的相关性。

Stroke:主动脉瘤或夹层修复术后脊髓梗死发生率分析!

由此可见,在主动脉夹层或主动脉瘤破裂患者修补术后脊髓梗死的发生约为每130例患者有1例,而在未破裂的主动脉瘤修复术后约为每600例患者出现1例。

盘点:主动脉瘤2016研究新进展一览

主动脉瘤是由于各种原因造成的主动脉壁局部或弥漫性向外扩张或膨出,逐渐发展成梭形或囊状的瘤样改变。根据不同的部位,主动脉瘤又可分为胸主动脉瘤和腹主动脉瘤。这里小M整理了2016年以来关于主动脉瘤的研究进展与大家分享。【1】喝绿茶可减少患腹主动脉瘤的风险最新研究表明,喝绿茶可以预防机体大动脉血管破裂。京都大学研究人员发现经常饮用绿茶多酚(绿茶的主要组成部分)的小鼠患腹主动脉瘤的发生率较低。Shuj