Dent Mater J:现代牙科用大块充填复合材料的细胞毒性:一项实时细胞分析

2019-10-03 lishiting MedSci原创

这篇研究的目的是通过实时细胞分析评估和比较现代牙科用流动和膏状大块充填复合材料的毒性。

这篇研究的目的是通过实时细胞分析评估和比较现代牙科用流动和膏状大块充填复合材料的毒性。

这篇研究通过L929小鼠成纤维细胞系比较了5种流动、5种膏状大块充填复合材料与1种常规流动和1种常规膏状复合树脂的毒性水平。将25,000 cells/300 μL/well细胞悬液放置于E-plate培养皿种后,添加测试材料并每30分钟观察一次直至72小时。采用Kruskal Wallis H和Mann Whitney U multiple comparison检验对结果进行统计学评估。

结果显示,包含预先起反应的玻璃离聚物(PRG)的大块充填复合材料在所有时间节点的毒性均较强(24, 48 and 72 h, p<0.05)。没有任何一种受测复合材料在48和72小时表现出较高的细胞活性(>70%)。同一品牌的流体和膏状复合材料表现出相似的毒性(p>0.05)。

原始出处:

Demirel G, Gür G, et al. Cytotoxic effects of contemporary bulk-fill dental composites: A real-time cell analysis. Dent Mater J. 2019 Sep 28. doi: 10.4012/dmj.2018-336.

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    2019-10-05 xzw115
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