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Regen Biomater：细胞在不同材料支架上其成骨能力不同

2018-04-14 MedSci MedSci原创

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本研究中，研究人员制备了胶原蛋白（COL）、胶原蛋白/羟基磷灰石（COL/HA）、HA和双相磷酸钙作为具有与骨类似的骨移植材料，并对其结构特征进行分析。 将大鼠骨髓间充质干细胞（BMSCs）接种到四组材料上，并将在基本培养基和标准成骨培养基中生长的BMSCs设置为对照组，以显示没有材料干预的细胞的基本和成骨行为。表征细胞行为，包括增殖、扩散形态和成骨因子的表达。 结果显示，随着时间的推

本研究中，研究人员制备了胶原蛋白（COL）、胶原蛋白/羟基磷灰石（COL/HA）、HA和双相磷酸钙作为具有与骨类似的骨移植材料，并对其结构特征进行分析。

将大鼠骨髓间充质干细胞（BMSCs）接种到四组材料上，并将在基本培养基和标准成骨培养基中生长的BMSCs设置为对照组，以显示没有材料干预的细胞的基本和成骨行为。表征细胞行为，包括增殖、扩散形态和成骨因子的表达。

结果显示，随着时间的推移，大鼠骨髓间充质干细胞在四组材料以及两组对照上适当增殖，观察到典型的立方形、多边形和极度伸长的细胞形态。实时聚合酶链反应结果显示，较高的成骨基因表达水平取决于细胞的生长形态而不是细胞的增殖速率，并且四组材料中细胞成骨分化的基因表达不同。一般来说，骨髓间充质干细胞在COL/HA上表现出最高的成骨能力，但在HA上最差。进一步探究了与对照组的OC和BC相比细胞在材料上的增长行为。

总之，本研究结果揭示了MSCs在材料上的成骨能力及材料的生物活性的差异。

原始出处：

Sun X, Su W, et al., Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen, collagen/hydroxyapatite, hydroxyapatite and biphasic calcium phosphate. Regen Biomater. 2018 Mar;5(2):93-103. doi: 10.1093/rb/rbx018. Epub 2017 Jun 30.

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    2018-09-14 sunylz

    #Bio#

    0

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    2018-04-17 wxl882001

    了解一下

    0

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    2018-04-16 zhaojie88

    #成骨#

    0

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    2018-04-14 131****1460

    学习了受益匪浅

    0

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    2018-04-14 虈亣靌

    学习了.获益匪浅.感谢分享

    0

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    2018-04-14 惠映实验室

    学习了.谢谢分享.

    0

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    2018-04-14 戒馋，懒，贪

    谢谢分享学习了

    0