J Thromb Haemost:再通对脑静脉血栓形成长期神经学结局的影响!

2018-01-17 xing.T MedSci原创

由此可见,大多数首次CVT患者在随访期间完全或部分再通。再通与有利的神经学结局独立相关的。

样本量有限且结果不一致的研究描述了脑静脉血栓形成(CVT)的再通时间过程。 CVT首次发作后的神经学结局是好的,但再通对神经依赖的作用仍然存在争议。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在评估CVT后的再通率及其对长期神经预后的作用。

在一项回顾性观察性多中心队列研究中,纳入了随访期间首次发生急性CVT并至少进行1次影像学检查的患者。血管的通畅状态被分类为完全的、部分的或不通。神经学结局是通过改良Rankin量表(mRS)来定义好(mRS=0-1)或差(mRS=2-6)。

该研究包含了510例(中位数(IQR)年龄39(28.5-49)岁; 26%为男性)患者。接受扫描的患者在不同的时间段(从28天至3个月至1-3年)的完全或部分再通率无差异。483例患者随访时可获得mRS和影像学检查;其中92.8%的mRS为0-1。CVT再通(比值比为2.56,95%可信区间为1.59-4.13)呈正相关,而癌症(比值比为0.29,95%可信区间为0.09-0.88)和个人静脉血栓栓塞史(VTE)(比值比为0.36,95%可信区间为0.14-0.92)与随访期间有利的(mRS=0-1)结局独立预测因子呈负相关。

由此可见,大多数首次CVT患者在随访期间完全或部分再通。再通与有利的神经学结局独立相关的。

原始出处:

E. Rezoagli,,et al.The effect of recanalization on long-term neurological outcome after cerebral venous thrombosis.Journal of Thrombosis and Haemostasis.2017.http://onlinelibrary.wiley.com/doi/10.1111/jth.13954/full

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    2018-11-25 changfy
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    2018-07-18 xue8602
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    2018-11-04 fusion
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    2018-01-21 半夏微凉

    学习了谢谢分享

    0

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    2018-01-17 小大夫快跑

    学习了.学习了

    0

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    2018-01-17 龙胆草

    学习谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2008334, encodeId=b165200833455, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Nov 25 15:18:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955338, encodeId=1e741955338cf, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Jul 18 00:18:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697618, encodeId=a128169e618fd, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sun Nov 04 22:18:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280761, encodeId=6c8d280e6108, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jan 21 20:32:14 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483262, encodeId=5e7414832620b, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Jan 18 23:18:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279355, encodeId=f5a42e9355db, content=学习了.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5Rzegz2kicwSDGST4gkzMm8229KtEaV7JEushLtsOJ4OweeyQ7oiaqU73G1eVialdQSZrH7DWxTgR8pYZ/0, createdBy=e81f1959878, createdName=小大夫快跑, createdTime=Wed Jan 17 09:52:53 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279351, encodeId=22e12e935184, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jan 17 09:31:56 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279342, encodeId=0f502e934290, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 17 09:25:14 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279337, encodeId=ee2b2e9337f5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Wed Jan 17 08:37:02 CST 2018, time=2018-01-17, status=1, ipAttribution=)]
    2018-01-17 明月清辉

    谢谢分享.学习了

    0

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    2018-01-17 1e17414fm02(暂无匿称)

    学习

    0

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