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Sci Rep：研究揭示黄连活性成分促进牙周膜干细胞成骨的机制

2018-03-16 MedSci MedSci原创

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黄连与hPDLSC/CMC上的膜受体结合，且从黄连中提取的活性成分小檗碱（BER）可促进牙周膜干细胞（hPDLSC）的增殖和成骨。但是，与hPDLSC的细胞表面上的BER结合的膜受体，BER与hPDLSC之间的直接相互作用的机制以及相关的信号通路目前尚不清楚。在这项研究中，研究人员发现EGFR为BER和hPDLSC之间的亲和膜受体，通过保留在CMC上，与BER的竞争，并通过使用分子对接模拟评分。同

黄连与hPDLSC/CMC上的膜受体结合，且从黄连中提取的活性成分小檗碱（BER）可促进牙周膜干细胞（hPDLSC）的增殖和成骨。但是，与hPDLSC的细胞表面上的BER结合的膜受体，BER与hPDLSC之间的直接相互作用的机制以及相关的信号通路目前尚不清楚。

在这项研究中，研究人员发现EGFR为BER和hPDLSC之间的亲和膜受体，通过保留在CMC上，与BER的竞争，并通过使用分子对接模拟评分。同时，使用MAPK PCR阵列筛选BER刺激hPDLSC时改变的靶基因。

结果显示，BER可能与hPDLSC细胞膜上的EGFR结合，从而激活细胞内ERK信号通路，使FOS的核相关基因发生改变，从而促进PDLSC的成骨作用。

原始出处：

Liu J, Zhao X, et al., The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR. Sci Rep. 2018 Feb 12;8(1):2848. doi: 10.1038/s41598-018-21116-3.

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    2018-07-12 xue8602

    #牙周膜干细胞#

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    2018-03-30 xqptu

    #牙周膜#

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    2018-03-18 zhaojie88

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    2018-03-18 liuyong2982

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