Int J Cardiol:年龄和性别对先天性心脏病成人存活率和死亡原因的影响!

2017-06-20 xing.T MedSci原创

由此可见,女性CHD患者的死亡率比男性要高。随着年龄的增长,CV死亡有所降低,但CV死亡的原因发生了重大的暂时性变化。在40以上的患者中,心脏衰竭超过猝死是幸存者的主要死亡原因。

性别和年龄对成年先天性心脏病(ACHD)患者相对存活率和死亡原因的影响尚不明确。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员对3311例ACHD患者(50.5%为男性)进行了单中心观察性纵向研究,对其随访了25年。

研究人员根据参与者最后一次随访的年龄分为三组,分别为<40岁, 40-65岁和>65岁组。其生命状态是由西班牙国家死亡指数验证检查的。研究人员对参考人群的相对存活率进行回归分析。死亡原因是根据国际疾病分类代码(ICD-10)来进行分类。研究人员对因心血管原因死亡的病人进行个案调查。

累积随访时间为37608人次每年,死亡336例(10%)患者。女性年龄调整后的相对存活率明显低于男性(风险比为1.25;95%可信区间为1-1.6;P=0.046),三个年龄组的性别调整后的相对存活率有所提高(风险比为0.98;95%可信区间为0.97-0.99;p<0.001)。随着年龄的增长,男性和女性的心血管死亡均呈下降趋势(p<0.001)。导致心血管死亡的主要原因是心力衰竭,但在40岁以下的患者主要为猝死(P=0.004)。而随着年龄的增长,猝死率逐渐下降,心衰逐渐增多(p<0.001)。

由此可见,女性CHD患者的死亡率比男性要高。随着年龄的增长,CV死亡有所降低,但CV死亡的原因发生了重大的暂时性变化。在40以上的患者中,心脏衰竭超过猝死是幸存者的主要死亡原因。

原始出处:

Jose Maria Olivera,et al. Impact of age and sex on survival and causes of death in adults with congenital heart disease. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2017.06.060

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    2017-06-22 huirong
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    2017-06-20 天涯183

    非常好的文章,学习了,很受益

    0

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    2017-06-20 lyh994

    随着年龄增加,损耗增加

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1862900, encodeId=6ef018629007e, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Wed Feb 14 15:39:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781765, encodeId=86291e817654e, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Aug 03 08:39:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903519, encodeId=86d3190351997, content=<a href='/topic/show?id=c8aa6335ed5' target=_blank style='color:#2F92EE;'>#死亡原因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63357, encryptionId=c8aa6335ed5, topicName=死亡原因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Sun Jun 25 18:39:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369293, encodeId=b4c013692936e, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Thu Jun 22 02:39:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213144, encodeId=872021314433, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Jun 20 13:43:53 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213123, encodeId=17792131230f, content=随着年龄增加,损耗增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Tue Jun 20 12:13:54 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213121, encodeId=ebf32131215d, content=学习了,好文章谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Jun 20 12:12:10 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213119, encodeId=ef83213119c7, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Tue Jun 20 12:06:56 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213112, encodeId=6ee621311211, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Tue Jun 20 11:48:27 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 1e0f8808m18(暂无匿称)

    学习了,好文章谢谢分享。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1862900, encodeId=6ef018629007e, content=<a href='/topic/show?id=b5ca453451f' target=_blank style='color:#2F92EE;'>#存活率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45345, encryptionId=b5ca453451f, topicName=存活率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Wed Feb 14 15:39:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781765, encodeId=86291e817654e, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Aug 03 08:39:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903519, encodeId=86d3190351997, content=<a href='/topic/show?id=c8aa6335ed5' target=_blank style='color:#2F92EE;'>#死亡原因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63357, encryptionId=c8aa6335ed5, topicName=死亡原因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Sun Jun 25 18:39:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369293, encodeId=b4c013692936e, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Thu Jun 22 02:39:00 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213144, encodeId=872021314433, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Jun 20 13:43:53 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213123, encodeId=17792131230f, content=随着年龄增加,损耗增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Tue Jun 20 12:13:54 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213121, encodeId=ebf32131215d, content=学习了,好文章谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Jun 20 12:12:10 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213119, encodeId=ef83213119c7, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Tue Jun 20 12:06:56 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213112, encodeId=6ee621311211, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Tue Jun 20 11:48:27 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-20 圣艮山

    学习了不少事情!

    0

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    2017-06-20 执着追梦

    学习,谢谢分享

    0

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研究人员发现了小于1岁的患者增强磁共振成像的DVAs的患病率非常低,显著低于其他年龄组。这些研究结果表明,在出生后静脉结构及引流模式的变化可能有助于DVAs的发展。

JCEM:年龄和抗体类型对1型糖尿病进展的影响(从单一到多种自身抗体)

既往的研究已经证明胰岛自身抗体是1型糖尿病的标志物,在临床前阶段检测到的自身抗体数量的增加预示着显性疾病的进展。本研究的目的是为了明确年龄与胰岛抗体类型的对1型糖尿病患者从单一到多种自身抗体的进展的影响。研究人员在TrialNet途径预防研究中前瞻性地对994名糖耐量正常且有一个自身抗体阳性的1型糖尿病患者进行了研究。研究人员对参与者的谷氨酸脱羧酶抗体(GADA)、胰岛素(IAA)、IA-2(IA

JASN:性别与肾移植失败的风险之间的相关性受年龄影响吗?

这些观察结果可能由几个因素的综合影响来解释,包括性别确定的轻微组织相容性抗原的识别、性激素对免疫激活的影响、药物依从性的性别和年龄相关的差异以及身体大小的性别相关差异。此外,进一步的研究应该确定对肾移植接受者是否有必要进行性别和年龄特异性的免疫抑制策略。

eLife:干细胞或是维持“老当益壮”的关键要素

近日,一项发表在国际杂志eLife上的研究报告中,来自罗彻斯特大学医学中心的研究人员通过研究发现,肌肉干细胞的缺失或是诱发老年小鼠肌肉功能衰退的主要原因,本文研究结果挑战了当前较为流行的理论,即运动神经元的缺失是诱发年龄相关肌肉功能下降的主要原因,研究人员希望后期能够开发出新型药物或疗法来减缓机体肌肉干细胞的缺失以及肌肉功能的下降。 图片

J Clin Periodontol:严重牙周炎患者疾病发病起始年龄分析:一项9-34年的回顾性研究

这篇研究的目的是回顾性分析30-45岁之间患有严重广泛性牙周炎的一组患者的发病起始年龄。