Mayo Clin Proc:降低全因死亡风险 摄入多少咖啡因为宜?

2017-09-01 吴星 环球医学

2017年8月,发表在《Mayo Clin Proc》的一项基于人群的前瞻性队列研究,考察了咖啡因摄入与全因和病因特异性死亡率之间的相关性。



2017年8月,发表在《Mayo Clin Proc》的一项基于人群的前瞻性队列研究,考察了咖啡因摄入与全因和病因特异性死亡率之间的相关性。

目的:评价咖啡因摄入是否与全因和病因特异性死亡率相关。

患者和方法:研究者使用国家健康与营养调查研究1999~2010中的数据,开展了一项前瞻性队列研究。使用Cox比例风险模型,比较咖啡因摄入10~99、100~199和≥200 mg/d的受试者与咖啡因摄入不足10 mg/d的受试者的校正多变量风险比(HRs)。

结果:共纳入17594例参与者,平均±SD和中位(四分位间距)随访时间分别为6.5±2.8年和6.4(3.6~9.5)年。17568例参与者(99.8%)完成随访,1310例死亡。与咖啡因摄入不足10 mg/d的参与者相比,咖啡因摄入10~99 mg/d(HR,0.81;95%CI,0.66~1.00;P=0.05)、100~199 mg/d(HR,0.63;95%CI,0.51~0.78;P<0.001)和≥200 mg/d(HR,0.69;95% CI,0.58~0.83;P<0.001)的参与者的全因死亡HRs和95% CIs显着较低。在每周摄入不足1杯咖啡的参与者中观察到了类似的相关性,咖啡因摄入100~199 mg/d的参与者的HR最低(HR,0.46;95% CI,0.22~0.93)。咖啡因摄入与心血管死亡之间无相关性,但咖啡因摄入10~99 mg/d(HR,0.74;95% CI,0.57~0.95;P=0.01)、100~199 mg/d(HR,0.60;95% CI,0.46~0.77;P<0.001)和≥200 mg/d(HR,0.65;95% CI,0.53~0.80;P<0.001)的参与者中,非心血管死亡的HRs显着较低。

结论:无论是否喝咖啡,咖啡因摄入适中与全因死亡风险降低相关。

原始出处:

Tsujimoto T, et al. Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study. Mayo Clin Proc. 2017 Aug;92(8):1190-1202. doi: 10.1016/j.mayocp.2017.03.010. Epub 2017 Jul 8.

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    2017-10-01 linlin2312
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    2017-09-03 sunylz
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    2017-09-01 131****1460

    学习了受益匪浅

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