Clin Oral Investig:牙周支持疗法过程中龈沟液的细胞因子水平

2019-01-04 lishiting MedSci原创

这篇研究的目的是为了长效评估牙周支持疗法(PMT)期间的依从性对细胞因子水平和它们与牙周状态之间关系的影响。

这篇研究的目的是为了长效评估牙周支持疗法(PMT)期间的依从性对细胞因子水平和它们与牙周状态之间关系的影响。

研究从212名接受PMT的患者中筛选出91名符合标准的个体进行本项术后6年的随访评估。从总数中随机选出28名患者作为规律性依从者(RC),选择年龄和性别相匹配的另28名患者作为非规律性依从者(IC)。所有受试者均为不吸烟者和非糖尿病患者。在5个时间点收集牙周参数和龈沟液样本:T1 [积极牙周治疗前(APT)], T2 (APT后), T3 (2 years), T4 (4 years)和T5 (6 years). 通过ELISA定量分析IL-6, IL-10, IL-1β, TNF-α和MMP-8的表达水平。

结果显示,与IC相比,RC随着时间的推移具有更好的临床牙周状态。随着时间的延长(from T1 to T5),RC的IL-1β, TNF-α, MMP-8和IL-6水平明显降低。相反,IC个体中的IL-6和TNF-α水平升高。而IL-10水平在RC中增加,在IC中降低。

结论:IC中炎症因子IL-1, TNF-α, IL-6和MMP-8代表着较差的临床指标,而在RC中IL-10代表着临床指标的明显改善。这些结果强化了这些因子在牙周炎发病机制中的角色,也表明了它们可以作为监测牙周炎进程的标志物。

临床意义:在积极牙周治疗后,6年时间PMT的规律性依从可以获得及维持较好的免疫和临床效果。

原始出处:

Costa FO, Cortelli SC, et al. Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy. Clin Oral Investig. 2018 Dec 11. doi: 10.1007/s00784-018-2770-x.

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    2019-11-27 小几洁
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  5. 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time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357395, encodeId=1d5d35e395ee, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Mon Jan 07 04:32:22 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283616, encodeId=fd0d12836163d, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Sun Jan 06 14:24:00 CST 2019, time=2019-01-06, status=1, 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  6. 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  7. 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  8. 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  9. 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  10. 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    2019-01-05 飛歌

    学习了很有用不错

    0

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