Gastroenterology:日常饮食、肠道炎症与结肠癌风险

2017-09-04 zhangfan MedSci原创

研究认为炎症饮食与结肠癌风险提高相关,与肿瘤间质淋巴细胞反应程度相关。该研究表明,饮食相关的炎症可能导致结直肠癌的发展

研究表明饮食模式对全身和局部肠道炎症存在影响,可能与结直肠癌风险相关。近日研究人员就日常饮食、肠道炎症与结直肠癌风险之间的关系进行了研究,同时考察淋巴细胞反应在其中发挥的作用。

研究人员从2项前瞻性队列研究中获得分子病理流行病学数据,使用Cox比例风险回归模型评估膳食炎症模式(EDIP)得分与结肠癌风险亚型之间的关系,膳食炎症模式评分高的食物包括红肉和加工肉类、精制谷物、碳酸饮料和一些蔬菜;评分低的食物包括啤酒,葡萄酒,咖啡,茶,黄色和叶菜类蔬菜以及果汁。对结直肠组织标本进行淋巴细胞反应模式的组织学分析,包括克罗恩病淋巴反应,癌周淋巴细胞反应,肿瘤周围反应和肿瘤浸润淋巴细胞。

共124433名志愿者参与研究,共报告了1311起结肠和直肠癌病例。研究发现食物的EDIP分数与结肠癌风险关系显著(P=0.02),且表现出不同程度的肿瘤间质淋巴细胞反应。研究发现,EDIP分数高的食物会增加结直肠癌风险,消除或降低肿瘤间质淋巴细胞反应(最高EDIPvs最低EDIP风险为2.60,95% CI,1.60-4.23; P <0 .001),但与肿瘤瘤周淋巴细胞反应程度不相关。

研究认为炎症饮食与结肠癌风险提高相关,与肿瘤间质淋巴细胞反应程度相关。该研究表明,饮食相关的炎症可能导致结直肠癌的发展。

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    2017-10-07 许安
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    2018-01-15 1215d1cdm89暂无昵称

    学习一下

    0

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createdBy=d58a435, createdName=sjq027, createdTime=Tue Dec 19 18:14:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242797, encodeId=9e5d242e97bc, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 11 08:00:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242227, encodeId=445424222ebb, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Sep 09 17:15:48 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241985, encodeId=97eb24198504, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 09 00:23:34 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414759, encodeId=c8e61414e5915, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2018-01-15 1215d1cdm89暂无昵称

    学习

    0

  5. 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createdBy=d58a435, createdName=sjq027, createdTime=Tue Dec 19 18:14:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242797, encodeId=9e5d242e97bc, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 11 08:00:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242227, encodeId=445424222ebb, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
  6. 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topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-12-19 sjq027
  7. 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topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-11 ylzr123

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Sep 09 17:15:48 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241985, encodeId=97eb24198504, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 09 00:23:34 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414759, encodeId=c8e61414e5915, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-09 flysky120

    学习一下知识

    0

  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Sep 09 17:15:48 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241985, encodeId=97eb24198504, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 09 00:23:34 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414759, encodeId=c8e61414e5915, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Wed Sep 06 05:14:00 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-09 thlabcde

    好东西学习了!

    0

  10. 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