Am J Gastroenterol:童年体重异常增加成年炎症性肠病风险

2018-03-14 zhangfan MedSci原创

研究发现儿童期间体重指数与成年后克罗恩病风险正相关,与溃疡性结肠炎风险负相关。儿童期肥胖是克罗恩病的潜在风险因素,相反儿童期消瘦是溃疡性结肠炎的风险因素

部分学者认为炎症性肠病(IBD)是一种肥胖相关的疾病,近日研究人员就儿童肥胖与成年期IBD风险之间的关系进行了考察。

CSHRR研究招募了316799参与者,考察参与者7-13岁时的体重指数与成年后IBD风险之间的关系,采用COX回归计算患者疾病风险比值比。

研究总计随访1000万患者年,其中克罗恩病确诊1500例,溃疡性结肠炎确诊2732例。7-13岁期间,体重指数每增加1单位导致参与者30岁后,溃疡性结肠炎风险降低(HR=0.9),但导致克罗恩病风险增加(HR 1.2)。

研究发现儿童期间体重指数与成年后克罗恩病风险正相关,与溃疡性结肠炎风险负相关。儿童期肥胖是克罗恩病的潜在风险因素,相反儿童期消瘦是溃疡性结肠炎的风险因素。

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    2019-01-02 许安
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    2018-03-18 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2072102, encodeId=749420e2102ab, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jan 02 15:20:00 CST 2019, time=2019-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064338, encodeId=7ec32064338c8, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Apr 13 21:20:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711414, encodeId=f9251e11414e8, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Jun 22 21:20:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297223, encodeId=f75129e22304, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Mar 18 00:12:41 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547121, encodeId=80cf154e1216f, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Mar 16 04:20:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296441, encodeId=54df296441da, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Mar 15 10:10:25 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296224, encodeId=b965296224ac, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Mar 14 21:03:39 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296211, encodeId=b50229621190, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Mar 14 19:54:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-15 虈亣靌

    了解一下.谢谢分享!

    0

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    2018-03-14 王秀

    学习了.涨知识了!

    0

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    2018-03-14 惠映实验室

    学习了.谢谢分享.

    0

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