J Gastroenterology:连锁彩色成像可通过与周围胃肠化生的高颜色对比增强对早期胃癌的识别效能

2019-05-05 不详 MedSci原创

消化道内镜通常被用来进行消化道癌症的筛查,而其中连锁彩色成像(LCI)可以增加早期胃癌的可见性,这可能与背景粘膜变成紫色的特征性表现有关。这些变紫的病变存在于慢性胃炎和周围粘膜区域。本研究的目的是评估是否可以通过LCI进行颜色差异和颜色成分值客观地区分癌症与正常组织。

背景
消化道内镜通常被用来进行消化道癌症的筛查,而其中连锁彩色成像(LCI)可以增加早期癌的可见性,这可能与背景粘膜变成紫色的特征性表现有关。这些变紫的病变存在于慢性炎和周围粘膜区域。本研究的目的是评估是否可以通过LCI进行颜色差异和颜色成分值客观地区分癌症与正常组织。

方法
研究人员招募了52名患有早期胃癌的患者,在行LCL时,对恶性病变和邻近粘膜中进行颜色差异的计算,并与切除的标本中的组织学发现进行比较。在慢性胃炎区域中比较L *,a *和b *的颜色分量值在紫色和非紫色粘膜之间。

结果
结果显示74%的病变中的癌症和周围粘膜使用白光成像(WLI)具有相似的颜色,而紫色粘膜使用LCI包围部分呈现橙红色,橙色或橙白色。与WLI相比,使用LCI观察到更大的色差以及更高的对比度。周围的紫色粘膜在组织学上与肠上皮化生相对应,有助于鉴别恶性病变。在慢性胃炎区域,40个病灶(83%)有紫色粘膜,8个病灶(17%)有非紫色粘膜,通过活组织检查诊断为肠上皮化生(准确率为83%)。紫色粘膜的颜色成分值与非紫色粘膜的颜色值显着不同。

结论
与WLI相比,LCI图像在早期胃癌和周围粘膜之间具有更高的颜色对比度。使用LCI的胃癌周围的特征性紫色代表肠上皮化生。

原始出处:

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    2019-05-05 许安
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    2019-05-07 楚钟

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