预防心脑血管病:为什么要降胆固醇?如何降?

2018-05-05 郭艺芳 郭艺芳心前沿

近来关于胆固醇的危害和降胆固醇的重要性有很多谣言,甚至有少数别有用心(旨在推销保健品)的人声称胆固醇无害,还有人宣称他汀是毒药。这些披着科普的外衣进行广告宣传的段子给很多人带来困惑:胆固醇是否有害?我们该不该控制胆固醇?

近来关于胆固醇的危害和降胆固醇的重要性有很多谣言,甚至有少数别有用心(旨在推销保健品)的人声称胆固醇无害,还有人宣称他汀是毒药。这些披着科普的外衣进行广告宣传的段子给很多人带来困惑:胆固醇是否有害?我们该不该控制胆固醇?实际上这个问题非常简单:我们都怕心脑血管病,因为心脑血管病是我国居民致死致残的首要原因。

发生冠心病(包括心肌梗死)和脑梗死的根本原因是动脉粥样斑块形成,而胆固醇是形成动脉粥样斑块的主要原料,没有胆固醇就没有动脉粥样硬化斑块,也就不会有心肌梗死和脑梗死。所以说,胆固醇增高肯定有害,只要胆固醇过高,就应该给予积极治疗。

高胆固醇血症是血脂异常最常见的表现形式之一,其起因主要是遗传因素和不健康生活方式两方面。例如,家族性高胆固醇血症主要由遗传因素所致,但临床上很多血脂异常患者是由饮食结构不合理、热量过剩、缺乏运动、超重或肥胖、酗酒等不健康生活习惯所引起的。所以防治血脂异常,长期坚持生活方式干预是最有效的措施,一定要控制饮食、增加运动、减轻体重、身心放松、生活规律、不要酗酒。

血脂异常以中年人群最为常见,由遗传因素所致者起病年龄较早,在青少年阶段即可发病。

在治疗方面,轻度或低危高胆固醇血症患者,经有效生活方式干预可将血脂参数控制在理想范围。即便必须应用药物治疗,积极有效的治疗性生活方式改善也有助于减少用药剂量。同时,强化生活方式干预还可对血压、血糖以及整体心血管健康状况产生有益的影响,有效降低心血管病的发病风险。

若经生活方式干预后,患者胆固醇水平不能达到目标值以下,或不能坚持有效生活方式干预,则应启动调脂药物治疗。

他汀类药物是最为可靠最为有效的降脂药物。此类药物不仅能够显着降低胆固醇水平,还能大幅度降低冠心病、心肌梗死、脑梗死等严重并发症的发生率。大多数人对他汀类药物的耐受性良好,不良反应通常较轻且短暂并与剂量相关,包括头痛、失眠、抑郁以及消化不良、腹泻、腹痛、恶心等消化道症状;有0.5%~2.0%的病例发生肝脏转氨酶升高。由他汀类药物引起并进展成肝功能衰竭的情况很罕见。减少他汀类药物剂量常可使升高的转氨酶回落;当再次增加剂量或选用另一种他汀类药物后,转氨酶常不一定再次升高。胆汁淤积和活动性肝病被列为他汀类药物的禁忌证。

肌病(包括肌痛、肌炎和横纹肌溶解)是他汀治疗过程中较为严重的不良反应,但单用标准剂量的他汀类药物治疗,很少发生肌炎。使用大剂量他汀或与其他药物合用时,包括环孢霉素、贝特类、大环内酯类抗生素、某些抗真菌药和烟酸类,肌炎的发生率会增加。虽然他汀类药物还可对糖代谢产生不利影响,并可能轻度增加新发糖尿病的发生率,但他汀治疗减少心血管事件的获益远远超过其升高血糖所带来的不利作用,故对于具备他汀治疗适应证的患者(包括糖尿病患者),应积极应用他汀治疗,同时需重视生活方式的干预。

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    2018-05-12 121ff658m46暂无昵称

    哦!谢谢!

    0

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    2018-05-09 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-05-07 yfjms

    学习

    0

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    2018-05-07 wzb521zf

    一起学习学习

    0

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    2018-05-06 smartxiuxiu

    科普!科普!

    0

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    2018-05-06 龙胆草

    学习谢谢分享

    0

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    2018-05-06 张新亮1853311252142e2fm

    好文献学习了

    0

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    2018-05-06 flysky120

    学习胆固醇的知识了

    0

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