J Gastroen Hepatol:糖尿病加速HCV感染者的癌变进程

2017-07-08 zhangfan MedSci原创

对于HCV感染患者,糖尿病会增加患者肝细胞癌的发病率以及全因死亡率

对于肝细胞癌(HCC) 以及HCV感染患者,糖尿病对肝癌死亡率的影响尚不清楚。近日研究人员根据台湾全民健康保险研究数据对糖尿病对肝癌的影响进行分析。

研究人员检索并招募新诊断糖尿病的HCV感染者,依据年龄、性别、酒精肝以及基线肝硬化程度倾向评分识别相应患者(n=1686)。利用多状态模型研究“开始到肝癌,“开始到死亡”和“肝癌到死亡”的转变过程。

研究发现,相对于非糖尿病患者,糖尿病病人发生“开始到肝癌,“开始到死亡”和“肝癌到死亡”的转变过程的风险更高。10年随访发现,糖尿病合并HCV感染患者的累积死亡率升高。多变量Cox过渡模型显示,对于糖尿病患者发生“开始到肝癌”过度的调整后风险升高(aHR 1.36; 95%,CI 1.16–1.59; P < 0.001),“开始到死亡”(aHR 2.61; 95% CI: 2.05–3.33; P < 0.001)以及“肝癌到死亡”(aHR 1.36; 95% CI 1.10–1.68; P = 0.005)升高。肝硬化对于“开始到肝癌”和“开始到死亡”过渡影响随时间的推移在2年内逐渐减弱。

对于HCV感染患者,糖尿病会增加患者肝细胞癌的发病率以及全因死亡率。

原始出处:


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    2017-09-28 许安
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    2017-07-10 吴教授

    糖尿病跟很多疾病都具有相关性

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Jul 10 00:53:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557049, encodeId=c51a155e04923, content=<a href='/topic/show?id=154be128170' target=_blank style='color:#2F92EE;'>#癌变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71281, encryptionId=154be128170, topicName=癌变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7914850828, createdName=axin014, createdTime=Mon Jul 10 00:53:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618979, 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encodeId=130f22006eeb, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:34:00 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 lou.minghong

    糖尿病全面影响代谢

    0

  5. 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    2017-07-10 ymljack
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    2017-07-10 gwc384
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    2017-07-10 axin014
  8. 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  9. 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encodeId=130f22006eeb, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:34:00 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 1dd8c52fm63(暂无匿称)

    了解了解

    0

  10. 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    2017-07-08 luominglian113

    学习了,谢谢分享

    0

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