SCI REP:血小板分布宽度与非小细胞肺癌预后相关!

2017-06-16 xing.T MedSci原创

总之,减少的血小板分布宽度是非小细胞肺癌患者生存结局不良的预测因素。但仍需要进一步的研究来予以证实。

血小板在肿瘤的进展和转移中起着多方面的作用。平均血小板体积(MPV)和血小板分布宽度(PDW)是常规血液检查中常用的血小板参数。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员旨在探讨非小细胞肺癌NSCLC)患者血小板指数与预后的关系。

研究人员回顾性地分析了在2009年1月至2009年12月期间被确诊为非小细胞肺癌的270例患者。研究人员收集了患者的特征以及初步诊断时的血液学检查数据,采用Kaplan-Meier法估计了总生存率。采用单因素和多变量Cox回归模型进行了预后分析。

研究人员发现减少的血小板分布宽度与T期、N期、TNM期以及疾病的组织学类型显著相关。此外,生存分析显示血小板分布宽度≥16.3%患者的总生存期要显著长于血小板分布宽度<16.3%的患者(P<0.001)。在多变量Cox回归模型中,年龄、性别、TNM分期和血小板分布宽度被确定为总生存期的独立预后因素(对于血小板分布宽度,P<0.001)。

总之,减少的血小板分布宽度是非小细胞肺癌患者生存结局不良的预测因素。但仍需要进一步的研究来予以证实。

原始出处:

Ming-ming Cui,et al. Platelet distribution width correlates with prognosis of non-small cell lung cancer.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-03772-z

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    2017-06-21 大爰

    学习了谢谢分享!

    0

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    2017-06-17 luominglian113

    学习了,谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1811928, encodeId=28901811928eb, content=<a href='/topic/show?id=380a8902024' target=_blank style='color:#2F92EE;'>#血小板分布宽度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89020, encryptionId=380a8902024, topicName=血小板分布宽度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ba9118, createdName=makuansheng, createdTime=Thu May 31 00:27:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059618, encodeId=1d1320596182b, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Nov 06 18:27:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213379, encodeId=cc7c2133e953, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jun 21 07:49:37 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211959, encodeId=48fe21195953, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jun 17 14:54:15 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211476, encodeId=44392114e6d9, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5vZbLiaw0G6FFQ3J4obXJNXbFJZBOJIsBiasEmSFCxzhibZ2TT0xftAW5kV1SLyo6jg0hOMaJg1Alm15kbuoDUFIsUM4JP7bdvcA/0, createdBy=10082062447, createdName=医无止境。, createdTime=Fri Jun 16 09:51:51 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211467, encodeId=ee1c21146edc, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Fri Jun 16 09:32:47 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211451, encodeId=0511211451ea, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Jun 16 09:12:02 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-06-16 医无止境。

    谢谢分享受益匪浅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1811928, encodeId=28901811928eb, content=<a href='/topic/show?id=380a8902024' target=_blank style='color:#2F92EE;'>#血小板分布宽度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89020, encryptionId=380a8902024, topicName=血小板分布宽度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ba9118, createdName=makuansheng, createdTime=Thu May 31 00:27:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059618, encodeId=1d1320596182b, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Nov 06 18:27:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213379, encodeId=cc7c2133e953, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jun 21 07:49:37 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211959, encodeId=48fe21195953, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jun 17 14:54:15 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211476, encodeId=44392114e6d9, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5vZbLiaw0G6FFQ3J4obXJNXbFJZBOJIsBiasEmSFCxzhibZ2TT0xftAW5kV1SLyo6jg0hOMaJg1Alm15kbuoDUFIsUM4JP7bdvcA/0, createdBy=10082062447, createdName=医无止境。, createdTime=Fri Jun 16 09:51:51 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211467, encodeId=ee1c21146edc, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Fri Jun 16 09:32:47 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211451, encodeId=0511211451ea, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Jun 16 09:12:02 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-06-16 我是谁??

    学习了。。。。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1811928, encodeId=28901811928eb, content=<a href='/topic/show?id=380a8902024' target=_blank style='color:#2F92EE;'>#血小板分布宽度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89020, encryptionId=380a8902024, topicName=血小板分布宽度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ba9118, createdName=makuansheng, createdTime=Thu May 31 00:27:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059618, encodeId=1d1320596182b, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Nov 06 18:27:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213379, encodeId=cc7c2133e953, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Jun 21 07:49:37 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211959, encodeId=48fe21195953, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jun 17 14:54:15 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211476, encodeId=44392114e6d9, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5vZbLiaw0G6FFQ3J4obXJNXbFJZBOJIsBiasEmSFCxzhibZ2TT0xftAW5kV1SLyo6jg0hOMaJg1Alm15kbuoDUFIsUM4JP7bdvcA/0, createdBy=10082062447, createdName=医无止境。, createdTime=Fri Jun 16 09:51:51 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211467, encodeId=ee1c21146edc, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Fri Jun 16 09:32:47 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211451, encodeId=0511211451ea, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Jun 16 09:12:02 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-06-16 执着追梦

    学习,谢谢分享

    0