J Clin Periodontol:牙周炎和血小板计数与心血管和其他全身炎症疾病的潜在联系

2018-11-16 MedSci MedSci原创

作为感染所致的炎性疾病,牙周炎可导致血小板计数的反应性增加。这种机制可以部分介导牙周炎与动脉粥样硬化性心血管疾病之间的关联。本文旨在研究韩国人群代表性样本中牙周炎和血小板计数之间是否存在关联。

作为感染所致的炎性疾病,牙周炎可导致血小板计数的反应性增加。这种机制可以部分介导牙周炎与动脉粥样硬化性血管疾病之间的关联。本文旨在研究韩国人群代表性样本中牙周炎和血小板计数之间是否存在关联。

方法:研究纳入了5,197名代表3490万成年人的受试者。应用多元回归分析控制年龄,性别,吸烟状况,教育水平,体重指数,酒精中毒,糖尿病高血压状态,维生素D血清水平和总胆固醇,甘油三酯,HDL和LDL血液水平。

结果:与非严重牙周炎组相比,在完全调整的模型中,患有重度牙周炎(CPI = 4)的受试者显示每微升血液的血小板增加了13,048.93(95%CI:3,296.26-22,801.61,p = 0.009)。重度牙周炎和血小板计数之间的关联已经在年龄大于60岁的受试者,女性,非吸烟者和HDL血液水平正常的人群中得到验证。全身性炎症生物标志物(白细胞计数)解释了这种关联的19.25%。

在该研究内,牙周炎, 尤其是重度牙周炎与血小板计数的显着增加独立相关,这至少部分地与全身性炎症的增加相关。

原始出处:

Mario Romandini, et al.Periodontitis and platelet count: A new potential link with cardiovascular and other systemic inflammatory diseases.Journal of Clinical Periodontal.2018 November. Doi:10.1111/jcpe.13004

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