Hepatology:CT和MRI对诊断肝细胞癌的的优劣

2017-09-02 MedSci MedSci原创

多相计算机断层扫描(CT)和磁共振成像(MRI)均可用于肝硬化肝细胞癌患者(HCC)的非侵入性诊断。近期,一项发表在杂志Hepatology上的研究旨在确定这两者之间是否存在相对的诊断优势,研究者们综合了CT,细胞外对比增强MRI和钆素增强MRI对肝硬化患者HCC诊断的相关性能的证据。此外,还评估了肝活检与对照替代成像的随访是否适用于肝硬化患者的CT或MRI不确定性肝结节。研究者们检索至2016年

多相计算机断层扫描(CT)和磁共振成像(MRI)均可用于肝硬化肝细胞癌患者(HCC)的非侵入性诊断


近期,一项发表在杂志Hepatology上的研究旨在确定这两者之间是否存在相对的诊断优势,研究者们综合了CT,细胞外对比增强MRI和钆素增强MRI对肝硬化患者HCC诊断的相关性能的证据。此外,还评估了肝活检与对照替代成像的随访是否适用于肝硬化患者的CT或MRI不确定性肝结节。

研究者们检索至2016年4月27日的多个数据库,选择在成年肝硬化和疑似HCC患者中,比较CT与细胞外对比增强MRI或钆素增强MRI的研究。此项研究由两位评审员独立选择研究并提取数据。

最终,在33项研究中,19项是综合性的,14项仅报告了敏感性。对于所有肿瘤大小,19项综合比较显示MRI显着高于CT检查的灵敏度(0.82 vs. 0.66)和较低的阴性似然比(0.20 vs. 0.37)。MRI与CT的特异性(0.91 vs. 0.92)和阳性似然比(8.8 vs. 8.1)没有差异。

对于≥2cm的HCC,上述三种方式表现均较佳。而对于HCC <1厘米的检查效果很差。没有研究评估使用活检,重复成像或替代成像来评估成人肝硬化和不确定结节的优劣。

此项研究表明:无法明确CT、细胞外对比增强MRI或钆素增强在诊断肝硬化患者的HCC中哪个更优。在肝硬化和质量不确定的患者中,没有足够的数据比较活检以及重复横断面成像或替代成像。

原始出处:
Roberts LR, Sirlin CB, et al. Imaging for the Diagnosis of Hepatocellular Carcinoma: a Systematic Review and Meta-analysis. Hepatology. 2017 Aug 31. doi: 10.1002/hep.29487.

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    2018-03-18 xjy02
  3. [GetPortalCommentsPageByObjectIdResponse(id=1978551, encodeId=15f819e855168, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Dec 05 17:59:00 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863301, encodeId=29ed1863301c3, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sun Mar 18 04:59:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240959, encodeId=8f2424095984, content=文章很好.赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 06 07:28:51 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240689, encodeId=fc81240689ba, content=非常好的文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Tue Sep 05 10:17:48 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426815, encodeId=4f9f1426815c5, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Sep 04 05:59:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239838, encodeId=e6d3239838d0, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Sep 02 23:12:37 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239806, encodeId=2bf123980677, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Sep 02 19:52:07 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239795, encodeId=8adb239e9590, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:28 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239776, encodeId=c9a4239e7603, content=肝癌影像学检查对照, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Sep 02 15:41:55 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-06 1e10c84am36(暂无匿称)

    文章很好.赞赞赞

    0

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    2017-09-05 1e1263e3m20(暂无匿称)

    非常好的文章不错

    0

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    2017-09-04 gwc384
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    2017-09-02 往日如昨

    继续学习中谢谢

    0

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    2017-09-02 天涯183

    非常好的文章.学习了

    0

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    2017-09-02 131****1460

    学习了受益匪浅.

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    2017-09-02 1e0f8808m18(暂无匿称)

    肝癌影像学检查对照

    0

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