Clin Oral Investig:多巴胺能通路基因的单核苷酸多态性与磨牙症的联系

2017-05-22 lishiting MedSci原创

这篇研究的目的是为了评估在治疗和控制磨牙症发生时,多巴胺能通路基因(DRD1, DRD2, DRD3, DRD4, DRD5和MAOB)中单核苷酸多态性(SNPs)的发生频率。

这篇研究的目的是为了评估在治疗和控制磨牙症发生时,多巴胺能通路基因(DRD1, DRD2, DRD3, DRD4, DRD5和MAOB)中单核苷酸多态性(SNPs)的发生频率。

研究将接受磨牙症治疗的患者分为3组:清醒磨牙症(61名患者)、睡眠磨牙症(26名患者)和清醒-睡眠磨牙症(43名患者)。对照组包含59名患者。昼夜节律表现与SNPs之间的联系通过Fisher精确测试、卡方测试、比值比的计算以及他们各自的95%置信区间进行检测。

结果显示,G等位基因DRD2 rs1800497 SNP与清醒-睡眠磨牙症风险的显著减小密切相关(p = 0.041),而C等位基因DRD3 rs6280 SNP与睡眠磨牙症风险的增高密切相关(p = 0.02),并且C等位基因DRD5 rs6283 SNP与清醒磨牙症风险的减少密切相关(p = 0.01)。

结论:据研究者所知,这是第1次基于昼夜节律的表现来检测多巴胺能通路的遗传变异对磨牙症发生和发展的影响。此次的研究结果表明,遗传因素可能对清醒、睡眠和清醒-睡眠磨牙症的病因学存在一定的影响。因此,需要更多的研究来增加我们对磨牙症生理病理学的认识。

原始出处

Oporto GH 5th, Bornhardt T, et al. Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism. Clin Oral Investig. 2017 Apr 27. doi: 10.1007/s00784-017-2117-z.

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    2018-03-05 小几洁
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    2017-07-29 xsm918
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  5. 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  6. 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    2017-05-24 jxrzshh
  7. 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    2017-05-24 xzw120
  8. 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    2017-05-22 wxl882001

    学习一下

    0

  9. 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    2017-05-22 1e0ece0dm09(暂无匿称)

    谢谢分享谢谢分享

    0

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