Clin Gastroenterology H: 酒精消耗和代谢综合征对肝病患者死亡率的影响

2019-07-14 不详 MedSci原创

有研究报道,代谢综合征和饮酒都会导致进行性肝病。本项研究的目的是评估饮酒和代谢综合征对脂肪肝患者死亡率的影响。

背景与目的
有研究报道,代谢综合征和饮酒都会导致进行性肝病。本项研究的目的是评估饮酒和代谢综合征对脂肪肝患者死亡率的影响。

方法
研究人员通过超声检测成人(20-74岁)肝脏脂肪变性的发生率,并随访至患者死亡或其他结局事件。研究人员从酒精使用问卷中收集数据(参与者自饮酒的自我报告天数;饮酒日每天饮酒量;参与者饮酒5天或以上的天数)并估计参与者每天饮酒的平均饮酒量。最后使用Cox比例风险模型来确定全因和特定原因死亡率的独立预测因子。

结果
该研究队列包括4264例肝脏脂肪变性患者(平均年龄45.9岁; 51%男性; 76%白人; 46%患有代谢综合征; 6.2%患有过量饮酒)。然而,在平均20年的随访后,酒精消耗过量的参与者(32.2%)与非过量饮酒的参与者(22.2%)的总体死亡率显着较高(P= .003)。在多变量分析中,代谢综合征([aHR],1.43; 95%CI,1.12-1.83)和过量饮酒(aHR,1.79; 95%CI,1.21-2.66)的存在与独立相关肝脏脂肪变性患者的死亡风险增加相关。

结论
本项研究发现酒精消费与脂肪肝和代谢综合征患者的死亡率增加是相关的。

原始出处:

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    2019-11-01 许安
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