J Am Heart Assoc: 糖尿病女性心血管并发症的发生更易受到空气污染的影响

2015-11-29 phylis 译 MedSci原创

背景:环境空气污染暴露与心血管疾病(CVD)发病率和死亡率有关。然而,最易受其不良影响的人群尚不清楚。方法和结果:研究者评估了护理健康研究中,114537名女性长期暴露于颗粒物下与CVD发生的相关性,对其进行分析,识别存在最大风险的亚群。应用时空预测模型估计,随时间变化的PM2.5,PM10及PM2.5到PM10之间的居住地水平。在多变量模型中,各种PM与CVD,冠心病,卒中的发生轻微升高相关,但

背景:环境空气污染暴露与心血管疾病(CVD)发病率和死亡率有关。然而,最易受其不良影响的人群尚不清楚。

方法和结果:研究者评估了护理健康研究中,114537名女性长期暴露于颗粒物下与CVD发生的相关性,对其进行分析,识别存在最大风险的亚群。应用时空预测模型估计,随时间变化的PM2.5、PM10及PM2.5到PM10之间的居住地水平。


在多变量模型中,各种PM与CVD、冠心病、卒中的发生轻微升高相关,但是没有显著的统计学差异。与无糖尿病女性相比,糖尿病女性患者PM相关CVD风险显著升高。12月平均PM2.5,PM2.5-PM10,PM10每增加10ug/m3 ,女性糖尿病患者多变量校正HR值分别为1.44(95%CI:1.23到1.68),1.17(95%CI:1.05至1.30),和1.19(95%CI:1.10,1.28)。 高龄(≥70岁)女性、肥胖及那些生活在东北和南部的人风险较高。吸烟和家族史不能改变PM值和CVD的相关性。

结论:在这一全国性队列研究中,糖尿病女性是PM值对不良心血管健康影响的最敏感人群。

原文出处:

Hart JE, Puett RC, Rexrode KM, et al. Effect Modification of Long-Term Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women. J Am Heart Assoc. 2015 Nov 25

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    2016-09-27 丁鹏鹏
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    2015-12-09 惜言

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    2015-11-30 zhaojie88
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    2015-11-30 slcumt

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