Immunology:MicroRNA通过调节Th17 / Treg的平衡来影响自身免疫性疾病

2018-08-27 MedSci MedSci原创

中国科学院深圳先进技术研究院生物医学与生物技术研究所的Liu C近日在Immunology杂志上发表了一篇重要的综述文章,系统性的总结了微小RNA(miRNA)对Th17 / Treg平衡的调节作用,及在自身免疫性疾病中的作用。

中国科学院深圳先进技术研究院生物医学与生物技术研究所的Liu C近日在Immunology杂志上发表了一篇重要的综述文章,系统性的总结了微小RNA(miRNA)对Th17 / Treg平衡的调节作用,及在自身免疫性疾病中的作用。

Th17细胞和调节性T(Treg)细胞是两种不同的T细胞亚群,它们对免疫功能具有相反的作用。虽然Th17细胞是免疫应答中的关键效应物,并且在自身免疫和炎症的发展中起关键作用,但Treg细胞通过调节效应T细胞的活性来协调整体免疫应答并维持外周免疫耐受。然而,Th17和Treg细胞的发育途径是相互关联的,它们之间存在大量的命运可塑性。干扰Th17 / Treg平衡对于自身免疫性疾病的发展有利,如EAE和多发性硬化症等。微小RNA(miRNA)是小的非编码RNA分子,主要在转录后调节基因表达。最近,新出现的证据表明,miRNA通过调节Th17 / Treg平衡,在调节自身免疫疾病的发病机制中发挥重要作用。本综述系统性概述了失调的miRNA及其在自身免疫疾病中调节Th17 / Treg平衡中的功能。

原文出处:

Liu, C., et al., MicroRNA-mediated Regulation of Th17/Treg Balance in Autoimmune Disease. Immunology, 2018.

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09:03:32 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341603, encodeId=6d9e34160314, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:28 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341602, encodeId=7145341602d4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:24 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341601, encodeId=c05234160186, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:21 CST 2018, time=2018-08-29, status=1, ipAttribution=)]
  5. 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09:03:32 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341603, encodeId=6d9e34160314, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:28 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341602, encodeId=7145341602d4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:24 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341601, encodeId=c05234160186, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:21 CST 2018, time=2018-08-29, status=1, ipAttribution=)]
    2018-08-29 zhouqu_8
  6. 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09:03:32 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341603, encodeId=6d9e34160314, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:28 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341602, encodeId=7145341602d4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:24 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341601, encodeId=c05234160186, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Aug 29 09:03:21 CST 2018, time=2018-08-29, status=1, ipAttribution=)]
    2018-08-29 zhaojie88
  7. 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    2018-08-29 xiaotao112411

    学习学习学习

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  8. 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    2018-08-29 xiaotao112411

    学习学习学习

    0

  9. 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    2018-08-29 xiaotao112411

    学习学习学习

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  10. 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    2018-08-29 xiaotao112411

    学习学习学习

    0

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大家都知道WNT信号传导是骨骼健康的基础,其异常活化导致骨骼病变。WNT1中的杂合错义突变p.C218G(WNT1是关键的WNT通路配体)导致严重的早发性和进行性骨质疏松症伴多发性外周和脊柱骨折。尽管骨骼表现严重,但常规骨转换标记在突变阳性患者中是正常的。2018年3月1日在JCEM上发表的一篇文章则研究了WNT信号受损患者的循环miRNA模式。

Oncogene:microR-106b被鉴定为是类p53膀胱癌的一种预后生物标记

膀胱癌可根据基因表达模式可以分为不同的亚型。类P53肌肉侵入型膀胱癌通常对基于铂的化疗具有抗性,并且展现了异质性的临床结果,且处于管腔亚型和基础亚型之间。对该亚型膀胱癌最优的治疗方法、能更好的对该类型肿瘤进行风险分层的方法以及新的治疗靶标的鉴定都是迫切需要解决的。MicroRNAs(miRNAs)在癌症的发生和肿瘤恶化过程中具有重要的作用。在过去的几年中,miRNA表达特征在不同类型的肿瘤中(包括

Hepatology:miRNA- seq鉴定了一个血清miRNA,结合APRI可以检测和监测存在囊性纤维化中的儿童肝病

本研究在儿科CFLD中发现了一种独特的循环miRNA,它有可能准确鉴别儿童CF患者的肝脏疾病和纤维化严重程度。

Clin Transl Oncol:microRNA-4319的重新表达能够抑制前列腺癌的生长

Her-2是一种表皮生长因子受体,并在一些前列腺癌(PC)中表达,且与肿瘤的外生长相关。一些microRNA的异常调节参与了PC发病机理的调控,然而miR-4319在PC中的角色仍旧未知。最近,有研究人员对miR-4319在PC中的作用进行了研究。研究人员通过RT-qPCR对miR-4319在PC组织中的水平进行了检测,并利用Kaplan-Meier分析调查了其表达水平与患者生存之间的相关性,并利