Radiology:小孩多动症在MR上会有什么改变呢?

2018-02-07 shaosai MedSci原创

本研究旨在验证注意力不良多动症(ADHD)诊断及分型相关的脑放射组学特征,基于以上特征建立诊断ADHD及其分型的分类,并将结果发表在Radiology上。

本研究旨在验证注意力不良多动症(ADHD)诊断及分型相关的脑放射组学特征,基于以上特征建立诊断ADHD及其分型的分类,并将结果发表在Radiology上。

本研究共纳入了83例新诊且未进行治疗的ADHD患者(平均年龄10.83岁± 2.30,年龄范围为7-14岁;男孩71例;其中注意力迟钝ADHD[ADHD-I]40例,ADHD-C或注意力迟钝并多动ADHD43例)及87名年龄和性别匹配健康志愿者(平均年龄11.21岁± 2.51;年龄范围为7-15岁; 男孩72名),并行常规及扩散张量磁共振(MR)成像。记录灰质形态特征及白质弥散特征的征象。将原始特征整合到所有相关特征选择程序中来验证具有显着诊断及分型的特征。在上述特征的基础上建立并评价随机森林分类系统。

结果为,在ADHD和对照组中脑体积(分别为1069830.00 mm 3 ± 90743.36 vs 1079 213.00 mm 3 ± 92742.25; P = .51)、灰质体积或白质体积(分别为611978.10 mm 3 ± 51622.81 vs 616960.20 mm 3 ± 51872.93; P = .53; 分别为413532.00 mm 3 ± 41 114.33 vs 418173.60 mm 3± 42395.48; P = .47)并无显着性差异。鉴别ADHD与对照组的分类系统的分类准确性达到73.7%。左侧颞叶、双侧楔回、中央沟旁皮层形态改变有易于两组进行鉴别诊断。鉴别ADHD-I与ADHD-C的分类真缺血为80.1%,以默认脑网络及岛叶特征最为显着。

本研究表明,颅脑形态学改变可能会鉴别ADHD与健康人甚至最常见的亚型。通过识别相关诊断及分型特征,有助于理解ADHD神经发育变化。

原始出处:


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    2018-02-09 chunjianf

    学习了.谢谢分享

    0

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    2018-02-08 lq1767
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    2018-02-07 飛歌

    学习了很有用不错

    0

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    2018-02-07 榄枷檬

    谢谢分享

    0

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    2018-02-07 榄枷檬

    学习学习

    0

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    2018-02-07 深海的鱼

    学习学习学习

    0

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    2018-02-07 wqkm

    ^_^^_^

    0

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    2018-02-07 yjs木玉

    好好好好好好好好

    0

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