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Biomacromolecules：化学 - 酶促合成的聚嵌段共聚物具有优良的抗菌性能

2018-05-02 MedSci MedSci原创

聚嵌段共聚物抗菌
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随着细菌污染和抗生素耐药性问题的日益增加，具有生物相容性和抗菌功效的新材料逐步开发用于生物医学应用。在此，我们展示了采用一锅两步法的化学-酶促开环聚合（ROP）方法用于嵌段共聚多酯，即聚（4-苄基甲酸酯哌啶内酯-b-ω-十五内酯）（PNPIL-b-PPDL）。之后，通过PNPIL-b-PPDL的酸性水解获得具有侧链仲氨基的阳离子聚（4-哌啶内酯-b-ω-十五内酯）（PPIL-b-PPDL）。所得到

随着细菌污染和抗生素耐药性问题的日益增加，具有生物相容性和抗菌功效的新材料逐步开发用于生物医学应用。

在此，我们展示了采用一锅两步法的化学-酶促开环聚合（ROP）方法用于嵌段共聚多酯，即聚（4-苄基甲酸酯哌啶内酯-b-ω-十五内酯）（PNPIL-b-PPDL）。之后，通过PNPIL-b-PPDL的酸性水解获得具有侧链仲氨基的阳离子聚（4-哌啶内酯-b-ω-十五内酯）（PPIL-b-PPDL）。

所得到的阳离子嵌段共聚酯对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌表现出高抗菌活性，而对NIH-3T3细胞显示低毒性。此外，该材料的抗菌性能、细胞毒性和降解行为可以简单地通过改变PPIL含量来调节。

因此，我们预计这种阳离子嵌段共聚物可能被用作药物或植入物的生物材料。

原始出处：

Xiao Y, Pan J, et al., Chemo-enzymatic synthesis of poly(4-piperidine lactone-b-ω-pentadecalactone) block copolymers as biomaterials with antibacterial properties. Biomacromolecules. 2018 Apr 26. doi: 10.1021/acs.biomac.8b00296.

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    2018-11-28 yb6560

    #MAC#

    0

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    2018-07-21 sunylz

    #Bio#

    0

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    2018-10-04 jiafufeng@yaho

    #CRO#

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    2018-05-04 ms7899726347904398

    #抗菌#

    0

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    2018-05-04 10518094zz

    #ACR#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1996157, encodeId=34e9199615ea5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Nov 28 04:19:00 CST 2018, time=2018-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918058, encodeId=7b1c191805848, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jul 21 15:19:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857635, encodeId=d12b185e635f0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Oct 04 18:19:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330703, encodeId=83131330e037d, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Fri May 04 04:19:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400383, encodeId=53a8140038387, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Fri May 04 04:19:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311322, encodeId=e9833113225b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 02 14:02:32 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-02 清风拂面

    谢谢分享学习

    0