Stroke:动脉瘤性蛛网膜下腔出血患者使用大麻脑血管风险增加

2016-04-09 MedSci MedSci原创

目前对于动脉瘤性蛛网膜下腔出血(aSAH)患者使用大麻事件,以及其对于发病率,死亡率和结果的影响都是未知的。该研究的目的是评估aSAH患者使用大麻和结果之间的关系。2010年和2015年之间,来自美国德克萨斯大学的研究人员对aSAH连续收治病人的记录进行了审查。尿液药物筛选为阴性的aSAH患者的临床特征及结果与大麻阳性(CB+)的结果进行了比较。回归分析用于评估关联性。该研究组共包括108例患者;

目前对于动脉瘤性蛛网膜下腔出血(aSAH)患者使用大麻事件,以及其对于发病率,死亡率和结果的影响都是未知的。该研究的目的是评估aSAH患者使用大麻和结果之间的关系。

2010年和2015年之间,来自美国德克萨斯大学的研究人员对aSAH连续收治病人的记录进行了审查。尿液药物筛选为阴性的aSAH患者的临床特征及结果与大麻阳性(CB+)的结果进行了比较。回归分析用于评估关联性。

该研究组共包括108例患者;25.9%的患者为使用CB+。50%的CB+患者和23.8%的尿液药物筛选阴性的患者被诊断为迟发性脑缺血(P=0.01)。CB+与迟发性脑缺血的发展独立相关(比值比,2.68;95%置信区间,1.03-6.99; P=0.01)。显著较多的CB+患者比尿液药物筛选阴性的患者有较差的结果(35.7% vs 13.8%,P=0.01)。在单因素分析中,CB+与住院病死率/重度残疾的复合终点相关(比值比,2.93;95%置信区间,1.07-8.01; P=0.04)。然而,在调整了其他预测因素后,这种作用已不再显著。

研究人员提供了的aSAH患者CB+与迟发性脑缺血和结果可能较差独立相关的初步数据。该调查结果增加了关于大麻与脑血管病风险的关联的证据。

原始出处:

Réza Behrouz,Lee Birnbaum,Ramesh Grandhi,et al.Cannabis Use and Outcomes in Patients With Aneurysmal Subarachnoid Hemorrhage,Stroke,2016.4.7

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    2016-04-14 李继凯

    文章不错

    0

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    2016-04-14 李继凯

    值得学习

    0

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    2016-04-11 kcb069
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