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Arterioscler Thromb Vasc Biol：MTHFR基因和血清叶酸相互作用降低血清同型半胱氨酸

2019-11-19 不详 网络

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这项CSPPT（中国卒中一级预防试验）事后分析评估了中国高血压成年人每天0.8 mg叶酸治疗平均4.5年后总同型半胱氨酸（tHcy）降低反应的个体差异，并通过亚甲基四氢叶酸还原酶（MTHFR）C677T基因型和血清叶酸水平评估效果改善。该分析包括来自CSPPT的16413名参与者，随机分为2个双盲治疗组：每天10 mg依那普利+ 0.8 mg叶酸组和10 mg依那普利组，基线和出访时分别测量血清叶

这项CSPPT（中国卒中一级预防试验）事后分析评估了中国高血压成年人每天0.8 mg叶酸治疗平均4.5年后总同型半胱氨酸（tHcy）降低反应的个体差异，并通过亚甲基四氢叶酸还原酶（MTHFR）C677T基因型和血清叶酸水平评估效果改善。

该分析包括来自CSPPT的16413名参与者，随机分为2个双盲治疗组：每天10 mg依那普利+ 0.8 mg叶酸组和10 mg依那普利组，基线和出访时分别测量血清叶酸和tHcy水平以及MTHFR C677T基因型。2个治疗组之间的平均基线tHcy水平相当（14.5±8.5 VS 14.4±8.1μmol/L；P = 0.561）。治疗4.5年后，依那普利+叶酸组的平均tHcy水平降低至12.7±6.1μmol/L，但依那普利组几乎保持相同（14.4±7.9μmol/L，组间差异为1.61μmol/L ；减少11％）。更重要的是，tHcy降低因MTHFR基因型和血清叶酸水平而异。与CC和CT基因型相比，TT基因型的参与者在tHcy和血清叶酸水平之间具有更突出的L形曲线，并且需要更高的叶酸水平（至少15 ng/mL）以消除基因型在tHcy中的差异。

综上所述，该研究结果表明，与CC或CT相比，TT组的tHcy从低叶酸水平到高叶酸水平呈升高L型曲线，但是当血浆叶酸水平达到≈15ng/mL或更高时，这种因基因型而出现的tHcy差异被消除。该研究结果提出了根据个体MTHFR C677T基因型和叶酸状况个性化定制叶酸疗法的前景。

原始出处：

Huang X, Qin X, et al., MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):679-685. doi: 10.1161/ATVBAHA.117.310211. Epub 2018 Jan 25.

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    2019-12-07 quxin068

    #ASC#

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    2020-10-16 medscijoin

    #相互作用#

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    2020-10-05 12498ebem31暂无昵称

    #Biol#

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    2020-03-24 sunylz

    #Bio#

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    2019-11-21 zhaojie88

    #ART#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1939004, encodeId=856319390044f, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Dec 07 11:44:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909289, encodeId=bd1819092895a, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Fri Oct 16 02:44:00 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767723, encodeId=1bea1e67723e6, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Oct 05 05:44:00 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918930, encodeId=467b1918930cd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Mar 24 02:44:00 CST 2020, time=2020-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357304, encodeId=a633135e3049a, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 21 11:44:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471647, encodeId=68e514e1647fa, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Thu Nov 21 11:44:00 CST 2019, time=2019-11-21, status=1, ipAttribution=)]
    2019-11-21 ylz8405

    #互作#

    0