Chest:心室舒张压比值可以作为肺动脉高压治疗反应的标志物

2017-05-26 xing.T MedSci原创

由此可见,LVEDP/RVEDP比值是一种采用肺血管扩张药物治疗的PH患者治疗反应的标志物,并可能提供强烈的预测价值,独立于已存的疾病严重程度标志。

肺动脉高压(PH)的诊断和分类是通过右心导管(RHC)来完成的,一系列血流动力学指标用来帮助指导治疗决策。这些标记可能不能反映复杂的右心室重塑或心室之间的相互作用,并努力预测治疗反应。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员旨在使用一个新的标志物:左侧与右侧心室舒张末期压力比值(LVEDP/RVEDP),来预测PH患者的队列的治疗结局。

研究人员在斐尔法克斯医院晚期肺病计划中接受同步左、右心导管检查的PH患者进行了回顾性分析。该研究的主要终点为临床改善的时间,定义为6MWT行走距离大于35米,且没有因PH恶化而住院或需要额外的PH治疗。

该研究共有51例患者纳入了最终的分析,其中21例(41.2%)患者出现了有益的治疗效应6MWT平均提高了75米。低LVEDP/RVEDP比值的患者治疗应答的可能性更高(1.08 vs. 1.62,P=0.051)。在最终的多元回归模型中校正了年龄、性别和控制肺动脉高压严重程度后这种相关性仍然存在(比值比为0.17,95%可信区间为0.03-0.65,P=0.024)。

由此可见,LVEDP/RVEDP比值是一种采用肺血管扩张药物治疗的PH患者治疗反应的标志物,并可能提供强烈的预测价值,独立于已存的疾病严重程度标志。

原始出处:

Arun Jose,et al. Ventricular diastolic pressure ratio as a marker of treatment response in pulmonary hypertension.chest.2017. http://journal.publications.chestnet.org/article.aspx?articleid=2629212

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    2018-04-17 Smile2680
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1822254, encodeId=32a218222544b, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed Nov 29 05:46:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929346, encodeId=091f19293461d, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Apr 17 10:46:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925164, encodeId=9f60192516440, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Aug 29 12:46:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841013, encodeId=f35b18410137c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jul 23 18:46:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050703, encodeId=79f62050e033f, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Dec 19 21:46:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323093, encodeId=7f5413230934d, content=<a href='/topic/show?id=80ca865895e' target=_blank style='color:#2F92EE;'>#舒张压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86589, encryptionId=80ca865895e, topicName=舒张压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun May 28 01:46:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203198, encodeId=16052031988d, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:18:52 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202849, encodeId=0d052028493f, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Fri May 26 16:37:53 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202762, encodeId=e2cc202e6255, content=心室舒张压学习知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri May 26 10:57:57 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-27 明天会更好!

    学习了,又涨知识了!

    0

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    2017-05-26 尹玉伟

    厉害厉害……学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1822254, encodeId=32a218222544b, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Wed Nov 29 05:46:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929346, encodeId=091f19293461d, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Apr 17 10:46:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925164, encodeId=9f60192516440, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Aug 29 12:46:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841013, encodeId=f35b18410137c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Jul 23 18:46:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050703, encodeId=79f62050e033f, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Dec 19 21:46:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323093, encodeId=7f5413230934d, content=<a href='/topic/show?id=80ca865895e' target=_blank style='color:#2F92EE;'>#舒张压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86589, encryptionId=80ca865895e, topicName=舒张压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun May 28 01:46:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203198, encodeId=16052031988d, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:18:52 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202849, encodeId=0d052028493f, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Fri May 26 16:37:53 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202762, encodeId=e2cc202e6255, content=心室舒张压学习知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri May 26 10:57:57 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 flysky120

    心室舒张压学习知识了

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