Nat Commun:研究进一步确定了肠道微生物与心血管疾病之间的关联

2017-10-23 MedSci MedSci原创

已知肠道微生物群已经与心血管疾病的发生有关,然而,肠道微生物的组成及功能与心血管疾病的关系目前尚未清楚。本研究纳入了218名动脉粥样硬化性心血管疾病(ACVD)患者和187名健康对照者,收集其粪便进行宏基因组关联研究。结果显示,ACVD患者肠道微生物菌群与健康对照者存在差异,其肠杆菌科和链球菌的丰度增加,且在功能上可作用心血管健康的几种重要分子的代谢或运输。虽然药物治疗是一个混杂因素,但ACVD的

已知肠道微生物群已经与心血管疾病的发生有关,然而,肠道微生物的组成及功能与心血管疾病的关系目前尚未清楚。

本研究纳入了218名动脉粥样硬化性心血管疾病(ACVD)患者和187名健康对照者,收集其粪便进行宏基因组关联研究。结果显示,ACVD患者肠道微生物菌群与健康对照者存在差异,其肠杆菌科和链球菌的丰度增加,且在功能上可作用心血管健康的几种重要分子的代谢或运输。虽然药物治疗是一个混杂因素,但ACVD的状态,而不是目前的药物使用,是该队列的主要特征。通过肠道微生物与其他心脏代谢疾病(肥胖和2型糖尿病)、肝硬化和类风湿性关节炎相关的数据进行比较,研究人员确定了共同的微生物。

总之,该研究进一步探究了肠道微生物群在促进或预防ACVD及其他相关疾病中的作用。

原始出处:

Zhuye Jie, Huihua Xia, et al., The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun. 2017; 8: 845. Published online 2017 Oct 10. doi: 10.1038/s41467-017-00900-1

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    2018-07-06 liuli5079
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    2018-06-30 liye789132251
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    2017-10-29 lou.minghong

    学习了谢谢分享!

    0

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    2017-10-24 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

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    2017-10-24 三生有幸9135

    学习一下谢谢分享

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