Blood:采用依鲁替尼治疗的慢性淋巴细胞白血病患者,早发性侵袭性真菌感染的相关风险

2018-02-04 MedSci MedSci原创

中心点:依鲁替尼可能与侵袭性真菌感染相关,特别是侵袭性曲霉菌感染。大部分感染通常发生在开始治疗的前几个月,常发生在存在其他真菌感染风险的患者中。摘要:依鲁替尼彻底改革了慢性淋巴细胞白血病的治疗方式,现在应用越来越多。尽管一直认为依鲁替尼比传统免疫疗法对患者的免疫抑制作用更弱,但在接受依鲁替尼治疗的患者中发生了几例侵袭性真菌感染,促使研究人员进行回顾性调查。研究人员对33位采用单一依鲁替尼治疗或联合

中心点:

依鲁替尼可能与侵袭性真菌感染相关,特别是侵袭性曲霉菌感染

大部分感染通常发生在开始治疗的前几个月,常发生在存在其他真菌感染风险的患者中。

摘要:

依鲁替尼彻底改革了慢性淋巴细胞白血病的治疗方式,现在应用越来越多。尽管一直认为依鲁替尼比传统免疫疗法对患者的免疫抑制作用更弱,但在接受依鲁替尼治疗的患者中发生了几例侵袭性真菌感染,促使研究人员进行回顾性调查。

研究人员对33位采用单一依鲁替尼治疗或联合使用依鲁替尼的并发生侵袭性真菌感染的患者进行鉴定。81.8%的患者(27/33)是侵袭性曲霉菌感染,40%感染曲霉菌的患者是大脑感染。

值得注意的是,大部分侵袭性真菌感染发生在依鲁替尼开始治疗的3个月(中位时间)后。在18例患者中,存在其他导致抗真菌反应减弱的因素,如使用糖皮质激素、中性粒细胞减少或联合免疫化疗。

总而言之,上述发现提示依鲁替尼可能与早发性侵袭性真菌感染相关,应密切监测使用依鲁替尼治疗的患者,特别是还存在其他导致真菌感染的风险因素的患者。

原始出处:

David Ghez,et al.Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib.Blood  2018  :blood-2017-11-818286;  doi: https://doi.org/10.1182/blood-2017-11-818286

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    2018-02-09 大爰

    学习了谢谢分享!!

    0

  5. 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CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285622, encodeId=9a0b28562239, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Feb 06 09:13:01 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-06 zhaojie88
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target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360333, encodeId=b2621360333cc, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), 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CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285622, encodeId=9a0b28562239, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Feb 06 09:13:01 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
  8. 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target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360333, encodeId=b2621360333cc, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), 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CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285622, encodeId=9a0b28562239, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Feb 06 09:13:01 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-06 sunyl07
  9. 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target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360333, encodeId=b2621360333cc, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Feb 06 13:41:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), 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CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285622, encodeId=9a0b28562239, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Feb 06 09:13:01 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-06 sunfeifeiyang

    0

  10. 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    2018-02-06 神功盖世

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