心血管

订阅

MedSci主页 / 所有栏目 / 心血管

PLoS ONE：感染幽门螺杆菌A型血者更易贫血

2012-11-29 PLoS ONE PLoS ONE

缺铁性贫血A型血幽门杆菌
关注

       我国科学家利用中科院上海光源BL08U1A线站，通过光学显微镜、扫描电子显微镜和同步辐射软X线成像分析等新技术，解析了幽门杆菌（Hp）感染相关贫血的分子机制，研究证明A型血的幽门杆菌感染者更容易贫血。相关研究结果11月21日在美国科学公共图书馆综合杂志PLoS ONE上发表。       &

       我国科学家利用中科院上海光源BL08U1A线站，通过光学显微镜、扫描电子显微镜和同步辐射软X线成像分析等新技术，解析了幽门杆菌（Hp）感染相关贫血的分子机制，研究证明A型血的幽门杆菌感染者更容易贫血。相关研究结果11月21日在美国科学公共图书馆综合杂志PLoS ONE上发表。

       据悉，缺铁性贫血是Hp携带者出现的胃外疾病之一，很多胃癌患者伴有严重的甚至是难治性贫血。上海交通大学医学院附属瑞金医院外科课题组在长期临床实践中发现，不同ABO血型对Hp的感染几率存在差异，其中以A型血个体的易感性较高。

本研究图解缺铁性贫血的新机制
图解缺铁性贫血的新机制
 
       瑞金医院外科王志威博士在导师于颖彦、朱正纲等教授指导下，与上海光源BL08U1A线站合作，将来自A、B、O和AB血型个体的红细胞分别与Hp共同孵育，然后观察与Hp紧密黏附的红细胞数量、形态变化以及铁元素分布。

       研究发现，A型血红细胞与Hp紧密黏附的数量明显多于其他血型红细胞。在BL08U1A线站L2和L3边双能软X线成像分析中，Hp菌体铁元素明显高于宿主红细胞，特别是当Hp与宿主红细胞共同孵育后，宿主红细胞内铁元素向与宿主细胞紧密黏附的Hp细菌转移。专家认为，该项研究首次揭示了临床难治性缺铁性贫血与Hp感染相关的分子机制，且这种相关性与宿主的ABO血型有关。

       该研究得到了国家科技部“863”计划重大项目、国家自然科学基金委、上海市科委优秀学科带头人计划以及上海交通大学医学院博士创新基金等资助。




Abstract 
Iron deficiency anemia is an extra-stomach disease experienced in H. pylori carriers. Individuals with type A blood are more prone to suffering from H. pylori infection than other individuals. To clarify the molecular mechanisms underlying H. pylori-associated anemia, we collected erythrocytes from A, B, O, and AB blood donors and analyzed morphology, the number of erythrocytes with H. pylori colonies attached to them, and iron contents in erythrocytes and H. pylori (NCTC11637 and SS1 strains) by means of optical microscopy, scanning electron microscopy, and synchrotron radiation soft X-ray imaging. The number of type A erythrocytes with H. pylori attached to them was significantly higher than that of other erythrocytes (P<0.05). Far more iron distribution was observed in H. pylori bacteria using dual energy analysis near the iron L2, 3 edges by soft X-ray imaging. Iron content was significantly reduced in host erythrocytes after 4 hours of exposure to H. pylori. H. pylori are able to adhere more strongly to type A erythrocytes, and this is related to iron shift from the host to the bacteria. This may explain the reasons for refractory iron deficiency anemia and elevated susceptibility to H. pylori infection in individuals with type A blood.

全文下载：

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1811667, encodeId=014a181166e2e, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 28 02:00:00 CST 2013, time=2013-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789486, encodeId=7a611e89486c7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Nov 01 16:00:00 CST 2013, time=2013-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1678120, encodeId=608d16e812081, content=<a href='/topic/show?id=7df63110d5' target=_blank style='color:#2F92EE;'>#A型血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3110, encryptionId=7df63110d5, topicName=A型血)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Jan 26 13:00:00 CST 2013, time=2013-01-26, status=1, ipAttribution=)]
    2013-07-28 kcb069

    #螺杆菌#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1811667, encodeId=014a181166e2e, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 28 02:00:00 CST 2013, time=2013-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789486, encodeId=7a611e89486c7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Nov 01 16:00:00 CST 2013, time=2013-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1678120, encodeId=608d16e812081, content=<a href='/topic/show?id=7df63110d5' target=_blank style='color:#2F92EE;'>#A型血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3110, encryptionId=7df63110d5, topicName=A型血)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Jan 26 13:00:00 CST 2013, time=2013-01-26, status=1, ipAttribution=)]
    2013-11-01 119337457

    #Plos one#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1811667, encodeId=014a181166e2e, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 28 02:00:00 CST 2013, time=2013-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789486, encodeId=7a611e89486c7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Nov 01 16:00:00 CST 2013, time=2013-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1678120, encodeId=608d16e812081, content=<a href='/topic/show?id=7df63110d5' target=_blank style='color:#2F92EE;'>#A型血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3110, encryptionId=7df63110d5, topicName=A型血)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Jan 26 13:00:00 CST 2013, time=2013-01-26, status=1, ipAttribution=)]
    2013-01-26 仁心济世

    #A型血#

    0