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徐兵河教授：Foundation One®在晚期乳腺癌中的应用

2018-06-19 佚名 肿瘤资讯

FoundationOne®晚期乳腺癌
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Foundation One®是一种全面基因组测序分析服务，针对所有实体肿瘤（除肉瘤以外）使用组织样本，应用“基于独特靶向富集杂交捕获”的NGS（二代测序）技术，在一次检测中平行提供了315个基因的4种基因变异及TMB和MSI两种基因标签的全面分子信息，更加精准地指导个体化靶向及免疫治疗方案。FoundationOne？的检测结果是经过严谨分析验证的， 同平台下的FoundationOne CDx

Foundation One®是一种全面基因组测序分析服务，针对所有实体肿瘤（除肉瘤以外）使用组织样本，应用“基于独特靶向富集杂交捕获”的NGS（二代测序）技术，在一次检测中平行提供了315个基因的4种基因变异及TMB和MSI两种基因标签的全面分子信息，更加精准地指导个体化靶向及免疫治疗方案。FoundationOne？的检测结果是经过严谨分析验证的， 同平台下的FoundationOne CDxTM是FDA和CMS批准的首个经过临床验证的NGS伴随诊断（CDx）。

激素受体阳性/HER-2阳性乳腺癌患者多线治疗后Foundation One®检测的临床价值

激素受体阳性乳腺癌最主要治疗手段为内分泌治疗，抗HER-2治疗是HER-2阳性乳腺癌的基础。任何治疗最终都可能产生耐药性，对于受体阳性的患者耐药之后的临床治疗仍然比较困惑。随着基因检测的普及，目前一些研究已显示出疗效，对非甾体类芳香化酶抑制剂耐药时，ESR1基因常发生突变，此时，改用氟维司群可能有效。针对HER-2阳性乳腺癌，目前的靶向药物包括曲妥珠单抗或拉帕替尼，但是耐药之后，临床上常常束手无策，其耐药机制、上下游的基因如何改变目前并未研究清楚，而二代测序能够很好地改善这种情况。Foundation One®的检测panel包括315个基因，具有如下优势：首先，检测深度方面，能够覆盖所有临床常见的基因变异（点突变，插入或缺失，拷贝数变化，融合）；其次，这种多基因联合检测可能发现复杂的多基因机制，可以指导乳腺癌的全程治疗，对于开展抗HER-2治疗或内分泌治疗非常有帮助，可指导临床医生选择耐药后的下一步治疗；第三，异病同治，无论原发病灶部位，只要关键的驱动基因相同，则可采取相同的治疗手段。例如HER-2阳性，无论乳腺癌或胃癌，甚至出现在其他肿瘤，都可以进行抗HER-2治疗。

所以这种多基因检测给临床提供了很多预测疗效、判断耐药以及采取下一步治疗的可靠的依据。

Foundation One®检测对TNBC患者治疗的意义

既往认为TNBC是一种疾病，随着研究深入，发现TNBC至少存在6种亚型，异质性非常强。进行多基因、深度的检测才能明确具体亚型。例如BRCA1/BRCA2突变的亚型，通过检测之后明确对PARP抑制剂及铂类药物敏感。雄激素受体阳性的亚型可进行抗雄激素治疗。免疫调节型TNBC患者可能对抗PD-1或PD-L1药物敏感。进行多基因检测后能够更深入了解TNBC各个亚型的本质及特点，对于临床开展针对TNBC的个体化治疗及精准治疗非常有帮助。

Foundation One®在国内上市的意义

Foundation One®是第一个被美国FDA批准的肿瘤NGS检测的产品，在国外临床应用的经验丰富，每年国际学术大会上也有很多应用FoundationOne？的经验，而国内现在有几百家做基因检测二代测序的公司，FoundationOne？的上市首先可以促进中国二代测序领域的发展。第二，可使临床检测更加规范。第三，为临床医生提供更多的治疗选择。第四，帮助医生进一步了解基因的复杂变异及肿瘤的耐药机制，选择下一步针对患者新的突变基因的药物，如果没有，是否能进一步开发新的靶向药物等等，对于临床和科研都非常有帮助。

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    2018-08-04 wleon8904

    #徐兵河#

    0

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    2018-07-03 zwjnj2

    好学习天天向上认真学习

    0

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    2018-06-21 12498a49m65暂无昵称

    #NDA#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1676775, encodeId=1a5f16e677504, content=<a href='/topic/show?id=4804503e4d0' target=_blank style='color:#2F92EE;'>#徐兵河#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50374, encryptionId=4804503e4d0, topicName=徐兵河)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=539727370645, createdName=wleon8904, createdTime=Sat Aug 04 01:16:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329033, encodeId=9d3a32903379, content=好学习天天向上认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Jul 03 20:05:38 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581053, encodeId=a8f215810539e, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Thu Jun 21 02:16:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325571, encodeId=7f953255e162, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Jun 20 09:17:27 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325526, encodeId=535832552635, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jun 20 06:55:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325522, encodeId=5bf8325522f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jun 20 06:53:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325356, encodeId=530732535642, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 19 11:32:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325350, encodeId=9e313253506b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Jun 19 11:29:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325342, encodeId=eb9a32534263, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jun 19 11:22:10 CST 2018, time=2018-06-19, status=1, ipAttribution=)]
    2018-06-20 Jackie Li

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1676775, encodeId=1a5f16e677504, content=<a href='/topic/show?id=4804503e4d0' target=_blank style='color:#2F92EE;'>#徐兵河#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50374, encryptionId=4804503e4d0, topicName=徐兵河)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=539727370645, createdName=wleon8904, createdTime=Sat Aug 04 01:16:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329033, encodeId=9d3a32903379, content=好学习天天向上认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Jul 03 20:05:38 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581053, encodeId=a8f215810539e, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Thu Jun 21 02:16:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325571, encodeId=7f953255e162, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Jun 20 09:17:27 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325526, encodeId=535832552635, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jun 20 06:55:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325522, encodeId=5bf8325522f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jun 20 06:53:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325356, encodeId=530732535642, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 19 11:32:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325350, encodeId=9e313253506b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Jun 19 11:29:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325342, encodeId=eb9a32534263, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jun 19 11:22:10 CST 2018, time=2018-06-19, status=1, ipAttribution=)]
    2018-06-20 sunfeifeiyang

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1676775, encodeId=1a5f16e677504, content=<a href='/topic/show?id=4804503e4d0' target=_blank style='color:#2F92EE;'>#徐兵河#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50374, encryptionId=4804503e4d0, topicName=徐兵河)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=539727370645, createdName=wleon8904, createdTime=Sat Aug 04 01:16:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329033, encodeId=9d3a32903379, content=好学习天天向上认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Jul 03 20:05:38 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581053, encodeId=a8f215810539e, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Thu Jun 21 02:16:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325571, encodeId=7f953255e162, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Jun 20 09:17:27 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325526, encodeId=535832552635, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jun 20 06:55:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325522, encodeId=5bf8325522f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jun 20 06:53:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325356, encodeId=530732535642, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 19 11:32:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325350, encodeId=9e313253506b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Jun 19 11:29:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325342, encodeId=eb9a32534263, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jun 19 11:22:10 CST 2018, time=2018-06-19, status=1, ipAttribution=)]
    2018-06-20 神功盖世

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1676775, encodeId=1a5f16e677504, content=<a href='/topic/show?id=4804503e4d0' target=_blank style='color:#2F92EE;'>#徐兵河#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50374, encryptionId=4804503e4d0, topicName=徐兵河)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=539727370645, createdName=wleon8904, createdTime=Sat Aug 04 01:16:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329033, encodeId=9d3a32903379, content=好学习天天向上认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Jul 03 20:05:38 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581053, encodeId=a8f215810539e, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Thu Jun 21 02:16:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325571, encodeId=7f953255e162, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Jun 20 09:17:27 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325526, encodeId=535832552635, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jun 20 06:55:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325522, encodeId=5bf8325522f8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jun 20 06:53:54 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325356, encodeId=530732535642, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jun 19 11:32:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325350, encodeId=9e313253506b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Jun 19 11:29:50 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325342, encodeId=eb9a32534263, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jun 19 11:22:10 CST 2018, time=2018-06-19, status=1, ipAttribution=)]
    2018-06-19 神功盖世

    阅

    0

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    2018-06-19 一个字-牛

    学习了谢谢分享

    0

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    2018-06-19 1ddf0692m34(暂无匿称)

    学习了.长知识

    0